Impact of Selenium on Microtubules Polymarisation of Spermatozoa of Endosulfan Exposed Swiss Albino Mice  

作　　者：Ranjit Kumar Jitendra Kumar Singh Mohammad Ali Arun Kumar 

机构地区：[1]Mahavir Cancer Sansthan ＆ Research Centre, Phulwarisharif, Patna 801505, India

出　　处：《Journal of Life Sciences》2011年第2期132-135,共4页生命科学（英文版）

摘　　要：Pesticide plays a vital role in agricultural, industrial and residemial pest control. In recent years the ‘pesticide problem＇ has been the focus of public interest because these chemicals have a very important role in agriculture but these chemicals also act like endocrine disruptor. Experiments were carried out on 12 weeks old mice with 30 ± 2 gm. b.w. Endosulfan were administered at 3 mg/kg b.w daily by gavage method for five weeks followed by selenium treatment at 10 μg/kg.b.w./day for five weeks. 9 ＋ 2 arrangment were clearly observed in control group mice with well structured dynein and nexin arm while Endosulfan treated group show depolymerised microtubule and 9 ＋ 1 arrangment with degenerated mitochondria. While selenium treated group shows restoration of 9 ＋ 2 arrangement of microtubule. It is evident from study that endosulfan causes depolymerisation of microtubule while selenium administered group show normal polymerized microtubule and restores normal fertility in mice.

关 键 词：SPERMATOZOA SELENIUM MICROTUBULES dynein arm nexin AXONEME depolymerisation Swiss albino mice 

分 类 号：Q245[生物学—细胞生物学] Q959.837