新的脑显像剂^(99m)Tc-ECD的研制——Ⅰ.合成与标记条件  

DEVELOPMENT OF ^(99m)Tc-ECD AS A NEW BRAIN IMAGING AGENT Ⅰ.SYNTHESIS AND LABELLING

作　　者：张小祥[1] 刘伯里[1] 金昱泰[1] 孔繁渊[2] 

机构地区：[1]北京师范大学化学系放射化学研究室 [2]宾夕法尼亚大学放射学系核医学室

出　　处：《同位素》1990年第2期73-78,共6页Journal of Isotopes

摘　　要：通过二步反应合成了ECD(Ethyl Cystenate Dimer)。利用^(99m)Tc-GH与ECD之间的配体交换反应,制得^(99m)Tc-ECD。研究了温度,pH值,Ca-GH的浓度,SnCl_2的浓度等对标记百分率的影响。结果表明,pH值的影响是非学重要的。ECD (Ethyl Cysteinate Dimer) was synthesized by two-step reactions. ECD was labeled with ligand exchange reaction between ^(99m)TcGH and ECD. The effect of temperature, PH Value, various quantities of Ca-GH, Sncl_2 on labelling percentage was studied. The effect of pH value is very important.

关 键 词：脑显像 显像剂 锝99 ECD 配体交换反应 

分 类 号：R817.41[医药卫生—影像医学与核医学]