侧基带有L-苯丙氨酸的手性两亲嵌段共聚物的合成及其自组装行为  

Synthesis and self-assembly behavior of chiral amphiphilic diblock copolymers bearing L-phenylalanine

作　　者：周勇[1] 汪瑾[2] 郭素珍[2] 

机构地区：[1]新乡学院化学与化工学院 [2]河南师范大学化学与环境科学学院

出　　处：《化学研究与应用》2011年第4期462-465,共4页Chemical Research and Application

基　　金：河南省2010年重点科技攻关项目(102102310283)

摘　　要：N3-苯丙氨酸与嵌段共聚物聚乙二醇-b-聚炔丙基缩水甘油(MPEO-b-PGPE)发生"click"反应,合成了具有光学活性的两亲嵌段共聚物聚乙二醇-b-聚L-苯丙氨酸三唑基缩水甘油(MPEO-b-PGTP),用1H-NMR和元素分析对其结构和组成进行表征。并对其自组装行为进行研究,滴体积法测定MPEO-b-PGTP溶液(pH=4.5)的临界胶束浓度为2.1mg/mL;用电子透射显微镜(TEM)直接观察聚合物MPEO-b-PGTP形成胶束的形态和尺寸;旋光仪测定结果表明其在水中自组装形成的胶束具有手性。Novel chiral amphiphilic diblock copolymers bearing L-phenylalanine was synthesized using a ＂click＂ reaction of N3-L-phenylalanine and MPEO-b-PGPE.The structure and composition of copolymers were characterized by 1H-NMR and elemental analysis.Additionally,the self-assembly behavior of these chiral copolymers was investigated in sodium dihydrogen phosphate buffer（pH 4.5）： the CMC of copolymer MPEO-b-PGTP determined by the measurement of surface tension was 2.1 mg/mL;the size and morphology of the micelles were studied using TEM;the specific optical rotation（[α]25D） of the micellar solutions was also measured;the result indicated that the copolymers can form chiral micelles in sodium dihydrogen phosphate buffer（pH =4.5）.

关 键 词：“click”反应 两亲嵌段聚合物 手性胶束 

分 类 号：O625.636[理学—有机化学]