宁夏枸杞叶对自然衰老小鼠的抗疲劳作用  

Effects of Lycium Barbarum Leaf on Anti-Fatigue in Ageing ICR Mice

作　　者：孙伟[1] 苗珍花[2] 王亚玲[3] 丁玉梅[4] 

机构地区：[1]宁夏医科大学医学科学技术研究中心,银川750004 [2]宁夏医科大学基础医学院人体解剖与组织胚胎学系,银川750004 [3]宁夏医科大学,银川750004 [4]宁夏医科大学附属医院,银川750004

出　　处：《宁夏医科大学学报》2011年第3期204-205,236,共3页Journal of Ningxia Medical University

基　　金：宁夏回族自治区自然科学基金资助项目(NZ09103);宁夏医科大学校级课题(XM2008-06)

摘　　要：目的观察枸杞叶(LBL)对自然衰老小鼠运动耐力和抗氧化作用的影响。方法 40只老年雄性自然衰老小鼠随机分为对照组和给LBL高、中、低剂量组(分别灌胃枸杞叶全汁10%、5%和2.5%),共4组,每组10只。各给药组每天灌胃0.2mL/10g,连续4周,对照组灌胃等量生理盐水。采用抗疲劳游泳试验进行运动耐力测试;用紫外分光光度计和试剂盒检测脑组织中单胺氧化酶(MAO)和谷胱甘肽过氧化物酶(GSH-px)活力。结果 LBL各剂量组均可使小鼠力竭游泳时间增加,MAO降低,GSH-px增加(P<0.05)。结论枸杞叶具有增强老年小鼠运动耐力、提高机体抗氧化的作用。Objective To explore the anti-fatigue effect of Lycium Barbarum Leaf（LBL） inn ageing ICR mice.Methods 40 ageing ICR mice were randomly divided into the control group and three LBL groups by pouring in stomach with LBL 10%,5 % and 2.5% respectively.After being dealt with for 4 weeks,Animals swam with free swimming in water.The level of monoamine oxidase（MAO） and glutathione peroxidase（GSH-px） in blood of animals were monitored by MAO kit and GSH-px kit.Results Compared with control group,swimming times of the LBL groups increased by 2.8%,7% and 29.6% respectively（P0.05）;MAO decreased by 60%,69.8% and 80.5%;GSH-px increased by 465.3%,563.8% and 635% respectively（P0.05）.Conlusion LBL shows anti-oxidative and anti-fatigue properties in ageing ICR mice.

关 键 词：枸杞叶 抗疲劳 抗氧化 老年小鼠 

分 类 号：R285.5[医药卫生—中药学]