乙型肝炎患者前S_1抗原与病毒血清学标志物及HBVDNA含量的相关性分析  

Correlation analysis between Pre-S_1 antigen and serological markers,HBV DNA in patients with hepatitis B

作　　者：郭晓霞[1] 

机构地区：[1]山西省中医院肝病科,山西太原030012

出　　处：《中西医结合肝病杂志》2011年第2期80-81,96,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:探讨乙型肝炎患者前S1(Pre-S1)抗原与病毒血清学标志物(HBV-M)、HBV DNA含量的相关性,以评价Pre-S1抗原检测的临床应用价值。方法:检测316例乙型肝炎患者病毒Pre-S1与HBV-M及HBV DNA含量,并进行相关性分析。结果:Pre-S1在HBeAg阳性患者中阳性率为95.7%,与HBeAg及HBV DNA具有相关性(P<0.01)。结论:Pre-S1与HBV DNA具有相关性,且较HBeAg更敏感,可以作为评价HBV复制的重要指标。Objective：To study the correlation between HBV Pre-S1 antigen,serological markers and HBV DNA copies,so as to assess the clinical value of Pre-S1 in detection of HBV replication.Methods：A total of 316 HBsAg-positive samples were collected.The levels of Pre-S1 antigen and serological markers and HBV DNA copies were determined.The correlation between the determination results was analyzed.Results：The positive rate of Pre-S1 antigen was 95.7% in the patients of e antigen positive Pre-S1 antigen level was correlated with the level of HBeAg and HBV DNA（P0.01）.Conclusion： Pre-S1 antigen is correlated with HBV DNA and is more sensitive and accurate than HBeAg in reflecting HBV replication.It may help assess the status of viral replication.

关 键 词：前S1抗原 病毒血清学标志物 E抗原 乙型肝炎病毒脱氧核糖核酸 

分 类 号：R512.62[医药卫生—内科学]