广西苦丁茶老叶水提取物的急性毒性作用研究  

Acute toxicity of water extract from old leaves of Guangxi kuding tea in mice

作　　者：符翠莉[1] 蒙大平[1] 荣延平[1] 黄雪梅[1] 路玫[1] 郭炎荣[1] 危华玲[1] 

机构地区：[1]广西壮族自治区人民医院药剂科,南宁530021

出　　处：《中国临床新医学》2011年第4期298-300,共3页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西科学研究与技术开发计划项目(编号:桂科攻0330001-1C)

摘　　要：目的探讨广西苦丁茶老叶水提取物对小鼠的急性毒性作用。方法以苦丁茶老叶水提取物溶液的最大浓度和最大给药体积给予小鼠灌胃,1次/d,连续7 d,观察和记录小鼠的毒副反应情况。结果试验期间小鼠活动状况与饮食情况均正常,未出现死亡和其它不良反应,解剖和尸检见内脏器官无异常。计算小鼠对苦丁茶的最大耐受剂量为87.2 g/kg,相当于成人日用量的耐受量174.4倍。结论广西苦丁茶老叶水提取物的毒性较低。Objective To observe acute toxicity of the water extract from old leaves of Guangxi kuding tea in mice. Methods The water extract from old leaves of Guangxi kuding tea was administered orally to mice with the greatest concentration and the largest volume. The administration was given once daily for seven consecutive days and the toxicity in mice was recorded. Results All experimented mice were survival and healthy. No significant change in body weight of mice and their toxicity were observed. The calculated maximum tolerant dose was 87.2 g/kg in mice, equivalent to that of 174.4 times in adults. Conclusion The water extract from old leaves of Guangxi kuding tea has lower toxicity.

关 键 词：广西苦丁茶老叶水提取物 小鼠 急性毒性实验 

分 类 号：R991[医药卫生—毒理学]