甘草反大戟的试验研究  

Restraining Effects of Radix glycyrrhizae on Radix knoxiae

作　　者：李冠军 

机构地区：[1]河北省张家口市畜牧技术推广站,河北张家口075000

出　　处：《畜牧与饲料科学》2011年第2期7-8,共2页Animal Husbandry and Feed Science

基　　金：河北省教育厅自然科学基金项目(2007103)

摘　　要：为观察中药"十八反"中甘草与大戟同用后的毒副反应,将试验动物分为甘草组、大戟组、甘草与大戟合煎组、甘草与大戟合剂组及对照组5组,分别灌服等量甘草、大戟、甘草与大戟合煎剂、甘草与大戟合剂和生理盐水,连续3d,观察记录动物的自发活动及死亡数。72h后处死取血,测定血清谷丙转氨酶含量,并做病理切片,进行血常规、肝体比、肾体比的测定。结果表明,单纯大戟对动物肝功能有一定影响,配伍甘草后对肝功能影响加重,但对肾功能则无明显影响。对肝脏、肾脏组织形态有一定影响,但停药后可以恢复。The study was aimed to observe poisonous side reaction after using Radix glycyrrhizae with Radix knoxiae of the Chinese ＂anti-18＂. The mice were assigned into five groups. The mice in the group Ⅰ, Ⅱ, Ⅲ, Ⅳ, Ⅴand CK were fed Radix glycyrrhizae decoction, Radix knoxiae decoction, dividual decoction of Radix glycyrrhizae and Radix knoxiae, admixture decoction of Radix glycyrrhizae and Radix knoxiae, and physiological saline, respectively, for 3 d. Spontaneous activity and fatality were recorded. The mice were executed after 72 h, and blood was collected for determination of glutamic-pyruvic transaminase level. Pathological section was prepared, and routine blood, liver/body ratio and kidney/body ratio was determined. The results showed that Radix knoxiae had a certain impact on liver function. Radix knoxiae compatible with Radix glycyrrhiza aggravated the impact on liver function but had no impact on kidney function. It also had effects on forms of liver and kidney organization, but they could recover after drug withdrawal.

关 键 词：甘草 大戟 配伍禁忌 小鼠 

分 类 号：R285.5[医药卫生—中药学]