回顾性分析近4年本院细菌耐药的发生率与变异率  

Retrospective analysis on incidence and aberration rate antibiotic-resistance of clinical isolates in Luhe Hospital of Beijing Tongzhou district in recently 4 years

作　　者：李晓辉[1] 林蕊艳[1] 胥振扬[1] 张虹霞[1] 张芳[1] 

机构地区：[1]首都医科大学潞河教学医院呼吸内科,北京通州101149

出　　处：《中国临床药理学杂志》2011年第4期276-279,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：目的回顾性分析本院近4年常见致病菌耐药性的发生率及变异率。方法收集本院2006年1月至2009年12月住院患者标本,并对其进行病原学培养及检测药敏,归纳与分析。结果本院近4年常见致病菌前5位,分别为铜绿假单胞菌(21.33%)、金黄色葡萄球菌(18.8%)、鲍曼/溶血不动杆菌(11.74%)、肺炎克雷伯菌(9.28%)、洛菲不动杆菌(5.67%)。G+球菌:金黄色葡萄球菌为主要致病菌,对万古霉素及利奈唑胺保持着100%的敏感性。G-杆菌仍是致病菌的主体菌群,且所占比例逐年增高;除阴沟肠杆菌对各类抗生素保持着较高的敏感性外,其余G-杆菌均表现出多重耐药性,仅对碳青霉烯类抗生素保持着较高的敏感性。结论细菌耐药情况日益严重,应做好细菌耐药监测工作,合理应用抗生素。Objective To analyze the incidence and aberration rate on antibiotic-resistance of clinical isolates in Luhe Hospital of Beijing Tongzhou district in recently 4 years.Methods Making antibiotic susceptibility test isolated from patients from January of 2006 to December of 2009 and analyzing the data.Results The first 5 common clinical bacteria were Pseudomonas aeruginosa（21.33%）,Staphylococcus aureus（18.8%）,Acinetobacer baumanii（11.74%）,Klebsiella pneumoniae（9.28%）,Acinetobacter lwoffii（5.67%）.Staphylococcus aureus was the major gram-positive pathogens,vancomycin and linezolid maintained 100 percent sensitivity.The incidence of gram-negative bacteria is higher than gram-positive bacteria and increased yearly.Gram-negative bacterias except Enterobacter cloacae show multiple drug resistance.Conclusion Drug-resistance in China is quite a big problem,it′s important and urgent to carry out resistance surveillance for appropriate using of antibiotics.

关 键 词：细菌培养 耐药性 敏感性 临床常见菌 

分 类 号：R969.3[医药卫生—药理学] R978.1[医药卫生—药学]