微乳液法制备多孔中空羟基磷灰石微球的研究  

Study on Porous Hydroxyapatite Microsphere with an Internal Cavity by Emulsion Method

作　　者：薛辉[1] 蔡玉荣[1] 姚菊明[1] 

机构地区：[1]浙江理工大学先进纺织材料与制备技术教育部重点实验室,杭州310018

出　　处：《浙江理工大学学报（自然科学版）》2011年第3期338-342,共5页Journal of Zhejiang Sci-Tech University(Natural Sciences)

基　　金：教育部新世纪优秀人才支持计划项目(NCET070763)

摘　　要：以自制的纳米羟基磷灰石粉末为原料,在明胶/水/植物油微乳体系中制得羟基磷灰石/明胶微球,经高温烧结将明胶去除后,得到多孔羟基磷灰石微球。采用TEM、XRD、TG、SEM、压汞仪对产品进行了表征。结果表明:利用本方法制得的羟基磷灰石微球尺寸较均匀,约为(800±200)μm;该微球呈现内部多孔结构,且孔隙率随微乳体系中明胶含量的增加而增加。当羟基磷灰石/明胶的质量比为4∶6时,微球出现空心现象。这种多孔且中空的羟基磷灰石微球在骨修复/填充和药物携带缓释方面具有潜在的应用前景。Using self-synthesizing hydroxyapatite as raw materials, the hydroxyapatite and gelatin composite microsphere is prepared in a gelatin/water/oil system via an emulsion method. Porous hydroxyapatite microsphere is fabricated after the gelatin is eliminated from the composite microsphere through sintering treatment. HA raw material and obtained microsphere are characterized by TEM, XRD, TG, SEM and Mercury determination. The results show that prepared HA raw materials are nanorod and HA microspheres are porous and have an average diameter of 800 m or so. With the increase of gelatin content in the emulsion system, porosity of HA microsphere increases. An internal cavity appears in the microsphere when the weight ratio of HA and gelatin in the emulsion system reaches 4.6. These porous hydroxyapatite microspheres with an internal cavity are promising candidates for filler of skeletal defects and drug carrier.

关 键 词：羟基磷灰石 明胶 微乳液法 多孔的空心微球 

分 类 号：TB383[一般工业技术—材料科学与工程]