硝酸布康唑缓释乳膏制备工艺的优化及体外释放度考察  

Optimization of preparation technology of butoconazole nitrate sustained-release cream and investigation of its in vitro release

作　　者：刘雷[1] 张朝晖[1] 吴小涛 李战 李纬 

机构地区：[1]江苏大学药学院,江苏镇江212013 [2]南京长澳医药科技有限公司,江苏南京210038

出　　处：《江苏大学学报（医学版）》2011年第2期171-174,共4页Journal of Jiangsu University：Medicine Edition

摘　　要：目的:制备硝酸布康唑缓释乳膏,考察其体外释放度。方法:采用正交设计优化制备工艺;采用HPLC法测定硝酸布康唑缓释乳膏的体外释放度。结果:最佳制备工艺为乳化温度90℃,乳化时间20 min,变速搅拌,制得样品有明显的缓释作用。结论:硝酸布康唑缓释乳膏的制备工艺稳定可行,所得样品有良好的缓释效果。Objective： To optimize preparation technology of hydrocortisone and chlorhexidine acetate cream and determine its release in vitro.Methods： The optimum preparation technology was selected by orthogonal test.Drug release was determined by method of HPLC.Results： The optimum preparation technology was established by emulsifying temperature of 90 ℃,emulsifying time of 20 min and agitating with variable speed,the samples had a slow release in vitro.Conclusion： The preparation procedure established was stable and practical,and the samples obtained showed good sustained release characteristics.

关 键 词：硝酸布康唑 缓释乳膏 制备工艺 体外释放度 

分 类 号：R944.2[医药卫生—药剂学]