各类滴眼剂对角膜上皮细胞的毒性—组织培养法研究  

Toxicity of various kinds of eye drops to cornealepitheliuma tissue culture assay study

作　　者：张泺[1] 邱良秀[1] 沈远平[1] 

机构地区：[1]同济医科大学附属同济医院眼科

出　　处：《眼科新进展》1999年第3期158-161,共4页Recent Advances in Ophthalmology

摘　　要：目的观察各类滴眼剂对人角膜上皮细胞的毒性，以便提供临床上对药物的评估。方法应用组织培养的方法，观察３０种滴眼剂的毒性。结果氯霉素（ｐＨ６．７）、庆大霉素（ｐＨ５．１）、磺胺类、喹诺酮类、咪唑类药物、地卡因、氧氰化汞等毒性较大。皮质类固醇的晚期毒性明显。结论我们认为滴眼剂的毒性与主药、防腐剂和溶剂的毒性有关，特别是ｐＨ值。为此我们要注意配方的科学性，妥善的存放和合理的用药。Objective To represent an evaluation of drugs in clinics by investigating the toxicity of various kinds of eye drops to human corneal epithelium. Methods Tissue culture assay was applied to investigate the toxicity of thirty kinds of eye drops in vitro. Result The toxicity of chloramphenicol(pH6.7),gentamicin(pH5.1),sulfonamides,fluoroquinolones,dicaine and hydroarygli oxcyanide were serious.Corticosteroids were more toxicant in late stages. Conclusion The toxicity of eye drops are related to several factors:the main drugs,the preservative agents,the disolved solution,particularly the pH values.

关 键 词：滴眼剂 毒性 角膜上皮细胞 

分 类 号：R988.1[医药卫生—药品]