心脏停搏液中盐酸戊乙奎醚对心肌功能的影响  

Effect of penehyclidine hydrochloride on myocardial function through cardioplegic solution

作　　者：胡艳[1] 罗红[2] 郭克芳[2] 李士通[1] 方浩[2] 

机构地区：[1]上海交通大学附属第一人民医院麻醉科,200080 [2]复旦大学附属中山医院麻醉科

出　　处：《临床麻醉学杂志》2011年第4期379-380,共2页Journal of Clinical Anesthesiology

摘　　要：目的观察经心脏停搏液使用盐酸戊乙奎醚对心肌功能的影响。方法二尖瓣手术患者20例,随机均分成两组。P组在心脏停搏液中加入1 mg盐酸戊乙奎醚,C组加入生理盐水。在麻醉诱导前(T1)、心包打开后(T2)、心肺转流(CPB)停止即刻(T3)、CPB结束后6 h(T4)、12 h(T5)、24 h(T6)、48 h(T7)检测心肌肌钙蛋白T(cTnT)、心肌酶谱、肌红蛋白(Mb)。结果 T3时两组cTnT、心肌酶谱、Mb均较T1时显著增高(P<0.05),但各时点组间比较差异无统计学意义。结论经心脏停搏液使用盐酸戊乙奎醚,无心肌保护作用,不引起术后谵妄。Objective To observe the effect of penehyclidine hydrochloride on myocardial function through cardioplegic solution. Methods Twenty patients scheduled for mitral valve replacement surgery were randomized into two groups： penehyclidine hydrochloride group （P group） and control group（C group）. In P group, 1mg（2ml） penehyclidine hydrochloride was added into the cardioplegic solution, in C group, 2ml sodium chloride was added. Troponin （cTnT）,myoglobin（Mb）, myocardium zymogram （CK, CK-MM, CK MB） was measured before anesthesia induction （T1）, after the incision of pericardium （T2）, at the end of CPB instantly （T3）, 6 hours （T4） , 12 hours （T5）, 24 hours （T6） and 48 hours after CPB（T7 ） respectively. Results At T3, cTnT, myocardial zymogram and Mb increased significantly in both groups compared with that of T1. No statistically significance was detected between the two groups in each time point. Conclusion Penehyclidine hydrochloride in cardioplegic solution can not produce myocardial protective effect. This administration method will not cause delirium.

关 键 词：心脏停搏液 盐酸戊乙奎醚 心肌保护 

分 类 号：R614[医药卫生—麻醉学]