肥胖2型糖尿病患者血浆内脂素水平的变化  

Change of Plasma Visfatin Level in Obese Patients with Type 2 Diabetes Mellitus

作　　者：周倩[1] 梁伟[1] 余绮玲[1] 陈定宇[1] 

机构地区：[1]广州市第一人民医院内分泌内科,广东510180

出　　处：《中国慢性病预防与控制》2011年第2期172-173,共2页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：目的探讨肥胖2型糖尿病患者血浆内脂素水平的变化。方法采用ELISA法检测106例我院内分泌科住院T2DM患者(T2DM组)和100例本院门诊健康体检者(对照组)的血浆内脂素水平,同时检测两组患者血糖、血脂代谢参数水平。结果 T2DM组非肥胖亚组与肥胖亚组的血浆内脂素水平分别高于对照组肥胖亚组与非肥胖亚组(P<0.01);T2DM肥胖亚组血浆内脂素水平高于非肥胖亚组,差异有统计学意义(P<0.01)。多元线性逐步回归分析显示WHR(t=3.412,P<0.01)和FPG(t=2.245,P<0.01)是影响血浆内脂素水平的独立相关因素。结论血浆内脂素水平变化与糖脂代谢关系密切,它可能在T2DM的发病机制中起着一定作用。Objective To investigate the change of plasma visfatin level in obese patients with type 2 diabetes mellitus （T2DM）. Methods ELISA method was employed to measure the plasma visfatin concentrations of obese 106 patients with T2DM （T2DM group） and 100 normal control subjects （control group）, and the levels of the indices of the glucose and lipid metabolism were determined. Results The plasma levels of the visfatin were considerably higher in both the non-obese and obese subgroup in T2DM group than those in the control group （P〈0.01）. In T2DM group, plasma visfatin of obese subgroup was significantly higher than that of the non-obese subgroup （P〈0.01）. The multiple linear regression analysis showed that only waist to hip ratio （WHR） （t=3.412, P〈0.01） and fasting plasma glucose （FPG） （t=2.245, P〈0.01） were independently associated with plasma visfatin level. Conclusion The change of plasma visfatin level is associated with glucose and lipid metabolism, which may play a role in the pathogenesis of T2DM.

关 键 词：内脂素 2型糖尿病 肥胖 

分 类 号：R587.1[医药卫生—内分泌]