袖状胃切除附加改良空回肠旁路术对GK大鼠血糖和血脂代谢的影响  

Effect of Sleeve Gastrectomy with Modified Jejunoileal Bypass on Blood Glucose and Blood Lipids in Goto-Kakizaki Rats

作　　者：朱占永[1] 罗晓[1] 严玲玲[1] 吴丹[1] 吴毅平[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院整形外科,武汉430030

出　　处：《华中科技大学学报（医学版）》2011年第2期200-203,208,共5页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：武汉市科技攻关计划(No.201060938360-07);华中科技大学研究生创新基金(No.HF-06-026-08-540)资助项目

摘　　要：目的探讨袖状胃切除附加改良空回肠旁路术对非肥胖2型糖尿病动物模型(GK大鼠)血糖和血脂代谢的影响。方法随机将21只GK大鼠分为袖状胃切除附加改良空回肠旁路术(SG/MJIB)组9只、假手术(sham-SG/MJIB)组6只和饮食配对(PF)组6只。动态观察手术前和术后16周中各组大鼠体重、进食量、空腹血糖、葡萄糖耐量、胰岛素耐量、胰岛素和脂质浓度的变化。结果自手术后第4周起,SG/MJIB组的体重增量明显低于sham-SG/MJIB组和PF组,差异有统计学意义(P<0.01)。SG/MJIB组空腹血糖较其它2组明显降低(P<0.05);SG/MJIB组术后2周OGTT曲线下面积(AUC)较其术前减少约38.9%(P<0.01),相对于其它2组差异有统计学意义(P<0.05)。与PF组和sham-SG/MJIB组相比,SG/MJIB组在术后的血脂浓度得到明显改善。结论 SG/MJIB可独立于体重和进食量的变化而直接有效地改善GK大鼠的血糖和血脂代谢。Objective To investigate the effect of sleeve gastrectomy with modified jejunoileal bypass（SG/MJIB）on the metabolism of blood glucose and blood lipids in the Goto-Kakizaki（GK）rats.Methods Twenty-one GK rats were randomly divided into SG/MJIB group（n=9）,sham-SG/MJIB group（n=6）and pair-fed（PF）group（n=6）.Before and after surgery during a duration of 16 weeks,the changes of weight gain,food intake,fasting glucose,oral glucose tolerance test（OGTT）,insulin tolerance test（ITT）,plasma insulin and lipid were observed.Results From the 4th postoperative week,the weight gain in SG/MJIB group was significantly decreased as compared with sham-SG/MJIB group and PF group（P0.01）.Fasting glucose concentration in SG/MJIB group was lower than in sham-SG/MJIB and PF groups（P0.05）.Two weeks after operation,glucose tolerance was improved in SG/MJIB group,and the area under the curve（AUC）of blood glucose concentration was decreased by about 38.9%（P0.01）as compared with those preoperation.These effects were not seen in sham-SG/MJIB and PF groups despite similar change of weight gain.Throughout the experiment period,the concentration of blood lipids in SG/MJIB group was obviously improved as compared with PF and sham-SG/MJIB groups.Conclusion SG/MJIB is directly and effectively linked to improve the metabolism of blood glucose and blood lipids in GK rats,independently of weight loss and caloric intake.

关 键 词：袖状胃切除术 空回肠旁路术 2型糖尿病 血糖 血脂 

分 类 号：R589[医药卫生—内分泌]