血清缺血修饰白蛋白和血浆脑钠肽联合检测在急性冠状动脉综合征中的临床应用探讨  

Clinical Application of Combined Detection of Ischemia Modified Albumin and Serum Brain Natriuretic Peptide in Acute Coronary Syndrome

作　　者：陈桂媛[1] 林涛[1] 高鹏霞[2] 

机构地区：[1]南京医科大学附属淮安第一医院检验科,江苏淮安223300 [2]南京医科大学附属淮安第一医院内分泌科,江苏淮安223300

出　　处：《标记免疫分析与临床》2011年第2期65-67,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：探讨血清缺血修饰白蛋白(ischemia-modified albumin,IMA)测定在急性冠状动脉综合征(acute coronary syndrome,ACS)的临床应用价值及与血浆脑钠肽(BNP)、肌钙蛋白Ι(cTnΙ)等标志物的相关性。检测56例ACS患者、38例非冠心病患者及72名健康对照者(对照组)的血清IMA、血浆BNP和cTnΙ等水平。与对照组比较,ACS组IMA值显著升高(P<0.01),非冠心病组无显著差异(P>0.05);ACS组血清IMA与血浆BNP呈正相关(r=0.322,P<0.01),与血浆cTnΙ无相关性(r=0.113,P>0.05)。结论:IMA是ACS早期敏感的指标,是评价早期出现的可逆性缺血的生化标志物。血清IMA与血浆BNP同时检测对临床诊断更有邦助。To explore the clinical value of detection of serum ischemia-modified albumin（IMA） in acute coronary syndrome（ACS） and the correlation with the plasma brain natriuretic peptide（BNP）and troponin Ι（cTnΙ）.The serum of IMA,BNP and cTnI in 56 cases of acute coronary syndrome,38 cases of non-coronary heart disease and 72 healthy controls were measured.The results showed that the serum level of IMA in patients with ACS were significantly increased（P0.01） and no significantly difference in non-coronary heart disease group（P0.05） compared with healthy control group.The serum IMA in ACS group was positively correlated with plasma BNP（r= 0.322,P0.01） and no correlation with plasma cTnΙ（r=0.113,P 0.05）.IMA is a sensitive marker for ACS and could be used as biochemical markers to evaluate the reversibility of the early stage of ischemia.The combined detection of serum IMA and plasma BNP would be very helpful for the clinical diagnosis of acute coronary syndrome.

关 键 词：缺血修饰白蛋白 脑钠肽 急性冠状动脉综合征 

分 类 号：R541.4[医药卫生—心血管疾病]