应用组织多普勒研究厄贝沙坦对房内传导的影响  

Evaluation of the relation between atrial conduction interval and irbesartan by Tissue Doppler Imaging

作　　者：刘锦[1,2] 杜波[3] 焦玉燕[3] 

机构地区：[1]青岛大学医学院,山东青岛266021 [2]山东省泰山医院,山东泰安271000 [3]泰山医学院附属泰山医院,山东泰安271000

出　　处：《泰山医学院学报》2011年第1期20-22,共3页Journal of Taishan Medical College

摘　　要：目的通过应用组织多普勒成像技术(TDI)研究血管紧张素Ⅱ受体阻滞剂对心房内传导时间的影响,以研究该类药物减少心房颤动的可能机制。方法将符合条件的高血压患者60例,随机分为试验组和对照组,分别给予厄贝沙坦及氨氯地平口服降压治疗,在服药前及服药后6个月行组织多普勒测量心房内传导间期。结果试验组房内传导间期服药后较服药前缩短(P<0.01),对照组服药前后无明显变化。结论厄贝沙坦对房内传导有影响(可以加快房内传导),组织多普勒成像法是一种较好的研究药物对心电生理影响的无创方法。Objective： To evaluate the relation between the atrial conduction interval and irbesartan by Tissue Doppler Imaging to research the possible mechanism of these drugs to reduce atrial fibrillation.Methods： Sixty patients with hypertension were randomly divided into the test group and the control group,the test group were given irbesartan oral treatment and the control group amlodipine were given oral treatment.Atrial conduction intervals were measured by Tissue Doppler Imaging medication before and 6 months after medication.Results： The atrial conduction interval of the test group after treatment is shorter than before treatment（P〈0.01）,Control group had no significant change before and after medication（P〉0.05）.Conclusion： Irbesartan has effect on intra-atrial influence,which can speed up the intra-atrial and TDI is a good method for the study of the impact of drugs on cardiac electrophysiology in non-invasive ways.

关 键 词：组织多普勒 ARB药物 房内传导间期 

分 类 号：R96[医药卫生—药理学]