莱芜地区HBV基因型分布及临床意义  

Distribution of hepatitis B virus genetypes in Laiwu area and its clinical relationship

作　　者：彭琳[1] 李菊 董学广[1] 

机构地区：[1]莱芜市人民医院检验科,山东莱芜271100 [2]莱芜市口镇中心医院检验科,山东莱芜271112

出　　处：《泰山医学院学报》2011年第1期49-51,共3页Journal of Taishan Medical College

摘　　要：目的了解莱芜地区乙型肝炎病毒(hepatitis B virus,HBV)基因型分布情况,探讨HBV基因型与临床的相关性。方法随机选择莱芜地区HBV感染患者231例,其中无症状HBV携带者45例,慢性乙型肝炎68例,乙型肝炎肝硬化65例,原发性肝癌53例。应用双波长实时荧光定量PCR技术,进行血清HBV基因分型测定。结果 231例标本中,216例(91.14%)可检出基因型,在阳性结果中B基因型39例(18.06%),C基因型179例(82.87%),B+C混合基因型5例(2.31%),未检出非B非C基因型。结论莱芜地区HBV感染者中,HBV基因主要存在C型,不同基因型与慢性乙型肝炎、肝硬化、原发性肝癌有相关性,C基因型HBV感染者较B基因型更易发展成肝硬化、原发性肝癌。Objective： To investigate the distribution of hepatitis B virus（HBV） genotypes in Laiwu area and explore its clinical relationship.Methods： HBV infections were randomly selected in Laiwu,of which 45 cases were asymptomatic HBV carriers,68 cases of chronic hepatitis B,65 cases of liver cirrhosis and 53 cases of primary liver cancer.Real-time PCR technology was used for determination of serum HBV genotyping.Results： 216 cases were detected for HBV genotype,of which B genotype was in 69 cases（18.06%）,C genotype 136 cases（82.87%）,and B＋C mixed genotype 5 patients（2.31%）.Conclusion： Genotype C is the most prevalent in all patient categories in this area.The results indicate that genotype C is associated with the development of severe liver disease.

关 键 词：肝炎病毒 乙型 基因型 分布 

分 类 号：R512.62[医药卫生—内科学]