糖尿病患者冠脉病变与非酒精性脂肪肝的关系研究  

Relationships between Coronary Heart Disease and Non-alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes

作　　者：邬月琴[1] 王云枝[1] 张柱[1] 乔庆红[1] 

机构地区：[1]包头医学院第一附属医院内分泌科,内蒙古包头014010

出　　处：《包头医学院学报》2011年第2期49-51,共3页Journal of Baotou Medical College

摘　　要：目的:探讨2型糖尿病(T2DM)患者冠脉病变的发生及其严重程度与非酒精性脂肪肝(NAFLD)的关系。方法:对2008年6月至2009年10月就诊的438例T2DM患者的临床资料进行回顾性分析,以是否合并NAFLD分组,比较组间冠心病(CHD)的发生率,对其中行冠脉造影的56例进行冠脉粥样硬化严重程度的相关因素分析。结果:T2DM合并NAFLD组CHD的发生率高于无NAFLD组(P<0.01),NAFLD与冠脉粥样硬化严重程度有关(χ2=21.95,P=0.000),T2DM合并NAFLD组发生严重冠脉粥样硬化是无NAFLD组的5.4倍。结论:T2DM患者CHD的发生及其严重程度与NAFLD密切相关,提示早期干预NAFLD可能减少CHD的发生,并减轻其严重性。Objective：To investigate the relationships between coronary heart disease（CHD） and non-alcoholic fatty liver disease（NAFLD） in patients with type 2 diabetes.Methods： From June of 2008 to October of 2009,a total of 438 patients with type 2 diabetes in our hospital were enrolled and were divided into two groups（NAFLD group vs.non-NAFLD group）.Then the data of them were analyzed retrospectively.Results： The incidence of CHD in patients with type 2 diabetes combining NAFLD was significantly higher than in patients with non-NAFLD.NAFLD was associated with the severe degree of CHD.The incidence of severe CHD in patients with type 2 diabetes combining NAFLD was 5.4 times as high as that in patients with non-NAFLD.Conclusion： NAFLD is associated with increased incidence and severe degree of CHD in patients with type 2 diabetes,which suggest early intervention of NAFLD may decrease the incidence and severe degree of CHD

关 键 词：2型糖尿病 冠状动脉粥样硬化 非酒精性脂肪肝 

分 类 号：R587.1[医药卫生—内分泌] R575.5[医药卫生—内科学]