电磁脉冲(EMP)辐照对雄性子代大鼠下丘脑GABA_A受体表达的影响  

Effects of Electromagnetic Pulse on the Expression of GABA_A Receptor in Hypothalamus of Male Offsprings of Rats

作　　者：杨明娟[1] 刘海强[1] 郭娟[1] 张琰君[1] 曾丽华[1] 郭国祯[1] 

机构地区：[1]第四军医大学放射医学教研室,陕西西安710032

出　　处：《现代生物医学进展》2011年第7期1257-1260,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金(No:60971055No:60871068);国际合作项目(No:2010DFA31900)

摘　　要：目的:观察电磁脉冲(EMP)辐照亲代大鼠后其雄性子代下丘脑GABAA受体表达的变化。方法:应用免疫组织化学及图像分析观察亲代大鼠接受EMP辐照后其雄性子代下丘脑GABAA受体表达的变化。结果:与对照组相比,100次脉冲组其雄性子代下丘脑室旁核GABAA受体阳性神经元增加,400次脉冲组光密度值显著增强;100次和400次脉冲组弓状核GABAA受体阳性神经元增加,光密度值增强。结论:电磁脉冲可以影响雄性子代下丘脑GABAA受体的表达,这可能与电磁脉冲辐射产生的远期遗传毒性有关。Objective：To investigate the relationship between the expression of GABAA receptor in hypothalamus of the offspring of male rats and electromagnetic pulse（EMP）.Methods：Immunocytochemistry combined with computer imaging analysis was carried out to examine the expression of the GABAA receptor in hypothalamus of male offspring.Results：Compared with the rats of control group,the expression of GABAA receptor increased in male offspring of 100 pulses group,the value of IOD increased in 400 pulses group;The expression of GABAA receptor in the arcuate nucleus increased.Conclusions：Electromagnetic pulse could induce the expression of GABAA receptor in hypothalamus of male offspring,which may be related to the long-term genetic toxicity of EMP.

关 键 词：电磁脉冲 雄性大鼠 子代 GABAA受体 

分 类 号：O64[理学—物理化学] Q95-3[理学—化学]