难治性抑郁症治疗前后血浆单胺类神经递质代谢产物的变化  

Refractory depression:changes of plasma monoamine neurotransmitter metabolite before and after treatment

作　　者：张延霞[1] 张桂青[1] 阮宁[1] 胡敏 赵倩 

机构地区：[1]石河子大学医学院护理系,新疆石河子832002 [2]河子大学医学院第一附属医院康复心理科,新疆石河子832002 [3]兰州市肺科医院,甘肃兰州730046

出　　处：《现代生物医学进展》2011年第7期1352-1354,共3页Progress in Modern Biomedicine

摘　　要：目的:探讨难治性抑郁症患者抗抑郁剂治疗前后的单胺类神经递质代谢产物的改变。方法:随机入组30例难治性抑郁症患者,进行汉密尔顿抑郁量表(HAMD)的临床评定。用酶联免疫吸附方法对这30例患者进行5-HIAA,MHPG检测,并与随机选取的经汉密尔顿抑郁量表(HAMD)临床评定的30名普通抑郁症患者进行比较。综合治疗8周后对难治性抑郁症患者进行治疗前后对比。结果:难治性抑郁症组治疗前血浆5-HIAA,MHPG浓度低于普通对照组(p<0.05),经5-羟色胺重摄取抑制剂治疗的难治性抑郁症患者,5-HIAA和MHPG含量与治疗前比较均有所升高,差异有显著性(p<0.05);结论:难治性抑郁症患者存在中枢5-羟色胺和去甲肾上腺素功能低下;个体化合理使用SSRIs类药物辅以心理治疗能有效地提高难治性抑郁症患者的外周单胺类递质水平,减轻患者的抑郁程度。Objective：To discuss variety of the metabolite products of monoamine neural transmitter in Treatment-Resistant de-pression（TRD） patients before and after therapy.Methods：Thirty TRD patients were recruited and assessed by using HAMD.Plasma levels of 5-HIAA,MHPG were evaluated and compared using ELISA method in 30 TRD patients and 30 normal depression patients who were recruited and assessed by using HAMD.After 8 weeks of combined treatment of TRD patients were compared before and after treatment.Results：The serous levels of 5-HIAA,MHPG before therapy in the TRD group were lower than those in the normal depres-sion patients group（p0.05）,And the levels were increased after therapy compared with the levers before therapy（p0.05）.After SSRI treatment,the 5-HIAA and MHPG content were increased compared with that before treatment（p0.05）.Conclusion：TRD patients have central 5-HT and norepinephrine dysfunction.Individual rational use of SSRIs drugs combined with psychological treatment can im-prove peripheral levels of monoamine neurotransmitters and reduce depression in TRD patients.

关 键 词：难治性抑郁症 5-HIAA MHPG 

分 类 号：R395.1[哲学宗教—心理学] R749.79[医药卫生—医学心理学]