北京石景山地区孕妇及婴幼儿游离红细胞原卟啉与血铅关系的研究  

Relationship Between Free Erythrocyte Protoporphrins and Blood Lead Among Pregnant Wemen and Their Infants in Shijingshan District,Beijing

作　　者：秦效英[1] 董兵[1] 刘建荣[1] 白雪涛[1] 郑星泉[1] 首钢医院课题组 

机构地区：[1]中国预防医学科学院环境卫生监测所,北京100021

出　　处：《环境与健康杂志》1999年第5期261-263,共3页Journal of Environment and Health

基　　金：中国预防医学科学院科研基金

摘　　要：为探讨低水平铅暴露人群体内游离红细胞原卟啉（ Ｆ Ｅ Ｐ）与血铅（ Ｐｂ Ｂ）的关系，在严格的质量保证措施下，对北京石景山地区２７０ 名孕妇及其婴幼儿进行了游离红细胞原卟啉及血铅的追踪研究。结果显示：孕妇血中 Ｆ Ｅ Ｐ水平为３１７～３８３ μｇ／ｄ Ｌ（ｎ＝ ５７８），脐带血中 Ｆ Ｅ Ｐ水平为４８８±２３６ μｇ／ｄ Ｌ（ｎ＝ １３３），婴幼儿各年龄组间 Ｆ Ｅ Ｐ水平无显著性差异，为３７２～３９５ μｇ／ｄ Ｌ（ｎ＝ ３５７），与正常人群的水平接近。本研究中无论孕妇还是婴幼儿，血铅值大部分低于０４８３μｍ ｏｌ／ Ｌ（１００ μｇ／ Ｌ）。经相关性分析，ｌｎ Ｆ Ｅ Ｐ与血铅值之间无相关关系（ Ｐ＞ ００５）。因此在低血铅水平， Ｆ Ｅ Ｐ测定不能作为铅暴露的监测指标。To research the relationship between free erythrocyte protoporphrins(FEP) and blood lead(PbB) among population exposed to low levels of lead,under strict quality control,a survey on FEP and PbB was carried out among 270 pregnant women and their infants in Shijingshan district,Beijing The results showed that the FEP levels in blood were 31 7~38 3 μg/dL( n =578) for pregnant wemen,the FEP levels in umbilical cord blood were 48 8±23 6 μg/dL( n =133),the significant differences of FEP levels(37 2~39 5 μg/dL, n =357)between various age groups of infants were not observed The FEP levels for pregnant women and their infants approached those for normal levels It also showed that the levels of PbB were below 0 483 μmol/L(100 μg/L)not only for most pregnant women but also for most infants The correlative analysis revealed that no correlation presented between the values of ln FEP and blood lead levels( P>0 05) It indicated that the FEP level should not be used as an suitable indicator for mornitoring lead exposure for population exposed to low levels of lead in the environment

关 键 词：北京 游离态 红细胞原卟啉 血铅 孕妇 婴幼儿 

分 类 号：X511.031[环境科学与工程—环境工程] X838