妊娠糖尿病患者C-P、HbAlc和hs-CRP的改变及意义  

The alteration and investigation of c-peptide,glycosylated hemoglobin and sensitive C-reactive protein test of gestational diabetes mellitus

作　　者：谢则金[1] 王厚照[1] 黄璐[1] 黄幼芳[1] 

机构地区：[1]解放军第174医院检验科,厦门361003

出　　处：《中国优生与遗传杂志》2011年第5期75-76,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨C肽(C-P)、糖化血红蛋白(HbAlc)和超敏C反应蛋白(hs-CRP)在妊娠糖尿病诊断中的临床意义。方法对正常对照组36例、正常妊娠组50例及妊娠糖尿病组56例采用生化和化学发光免疫方法进行hs-CRP、HbAlc、C-P的测定。结果妊娠糖尿病组hs-CRP、HbAlc和C-P结果与正常妊娠组相比均明显增高(P<0.01);C-P对妊娠糖尿病诊断的特异性高于HbAlc(P<0.05);阳性预测值为91.42%,也明显高于HbAlc(P<0.05);两者联合检测的结果中,联合检测的特异性和阳性预测值分别为98.84%和96.77%,明显高于两者单独检测的结果(P<0.05)。结论 hs-CRP、HbAlc、C-P在妊娠糖尿病诊断和监测中具有重要意义,联合检测HbAlc、C-P有利于提高妊娠糖尿病检测的特异性。Objective：To explore the clinical value of c-peptide,glycosylated hemoglobin and sensitive C-reactive protein test in diagnosis of gestational diabetes mellitus.Methods：36 cases health control,56 cases of gestational diabetes mellitus and 50 cases of normal pregnant women were selected.C-peptide,glycosylated hemoglobin and sensitive C-reactive protein test were measured by biochemical and chemiluminescence immunoassay methods.Results：Compared with the control and the normal pregnant group,the values of glycosylated hemoglobin,C-peptide and sensitive C-reactive protein were higher apparently in the gestational diabetes mellitus group（P〈0.01）.The specificity of c-peptide were significantly higher than glycosylated hemoglobin in the gestational diabetes mellitus;The specificity and the positive（98.84%and 96.77%） predictive value of combined detection of aglycosylated hemoglobin and c-peptide were significantly higher than Single detection（P〈0.05）.Conclusions：There were high value of c-peptide,glycosylated hemoglobin and sensitive C-reactive protein test in diagnosis of gestational diabetes mellitus;Combined detection of C-peptide,glycosylated hemoglobin will improve the specificity of gestational diabetes mellitus detection.

关 键 词：妊娠糖尿病 糖化血红蛋白 C肽 超敏C反应蛋白 

分 类 号：R714.25[医药卫生—妇产科学]