吸烟对慢性阻塞性肺疾病患者T细胞功能的影响  

The effect of smoking on T lymphocytes in patients with chronic obstructive pulmonary disease

作　　者：陈菁[1] 徐清[1] 杨硕[1] 刘梦琳[1] 聂红[1] 孙洁民[1] 

机构地区：[1]武汉市第一医院呼吸科,430022

出　　处：《临床内科杂志》2011年第4期240-242,共3页Journal of Clinical Internal Medicine

基　　金：湖北省自然科学基金资助项目（编号：2005ABA210）

摘　　要：目的评价吸烟对慢性阻塞性肺疾病（COPD）患者急性加重期、稳定期T细胞功能的影响。方法根据患者吸烟史将患者分为无吸烟史的对照组（A组）、非吸烟的COPD组（B组）、未戒烟的COPD组（C组）和已戒烟的COPD组（D组）；测定各组患者急性加重期、稳定期支气管肺泡灌洗液（BALF）和外周血CD3＋、CD4＋、CD8＋T细胞和CD4＋／CD8＋水平。结果COPD患者急性加重期BALF和外周血中CD3＋、CD4＋、CD8＋、CD4＋／CD8＋与对照组比较均有明显差异（P〈0．05）；其中未戒烟的急性加重期患者BALF中CD4＋下降（P〈0．05）、CD8＋上升（P〈0．05）、CD4＋／CD8＋下降（P〈0.05），稳定期患者BALF中CD4＋／CD8＋下降（P〈0．05）。结论未戒烟的COPD患者在急性加重期T细胞功能下降显著，在稳定期气道T细胞功能仍明显低下。Objective To investigate the effect on T lymphocytes influenced by smoking in patients with chronic obstructive pulmonary disease（COPD） during their acute and stable periods. Methods According to the smoking history, we divided the patients into 4 groups ： Group A ： Contral group ; Group B-COPD without smoking history;Group C：COPD with smoking history that has not been quit;Group D： COPD with smoking history that has been quit at least 10 years. The levels of CD3 , CD4, CDs , CD4＋ / CD＋ in blood and bronchoalveolar lavage fluid （BALF） were detected. Results The levels of CD＋, CD＋ ,CD＋ ,CD4＋/CD8＋ in blood and BALF were significantly different between COPD groups and normal group during their acute and stable periods（ P 〈 0.05 ）. The CD4＋ and CD4＋/CD8＋ in BALF declined（ P 〈 0.05） and CD8＋ raised （P 〈 0.05 ） during their acute periods, while CD4＋/CDs （P 〈 0.05 ） declined during their stable periods in patients who somke consistently. Conclusions The systemic immune function droped significantly in patients with COPD during acute period who smoked consistently, while the airway immune function still decreased in their stable periods.

关 键 词：吸烟 慢性阻塞性肺疾病 T细胞 

分 类 号：R563[医药卫生—呼吸系统]