嗅鞘细胞生物学特性及其表达的相关分子  

Olfactory ensheathing cells:cellular biology and molecular properties

作　　者：陈晶晶[1] 袁一曼[1] 苏志达[1] 

机构地区：[1]第二军医大学基础部神经科学研究所,分子神经生物学教育部重点实验室,长征医院神经科学研究中心,上海200433

出　　处：《第二军医大学学报》2011年第3期323-328,共6页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(30700209)~~

摘　　要：嗅鞘细胞(olfactory ensheathing cells,OECs)起源于外周神经系统(嗅基板),可穿越外周与中枢之间的屏障进入中枢神经系统,是嗅觉系统内一类特殊的胶质细胞。OECs在整个嗅觉通路中包绕在嗅神经外周,伴随其进入嗅中枢,在嗅神经生长和再生中发挥重要作用。OECs是目前移植治疗中枢神经损伤的重要候选细胞之一。其生物学特点是由特异表达的分子决定的,这些分子包括PDGF、NDY、S-100和Nestin等。目前实验室中常用p75NTR标记OECs的定位与分布,尚缺乏可以特异标记OECs的分子,将其与神经膜细胞和星形胶质细胞区分开。本文就OECs生物学特性及其表达的相关分子作一简要综述。Olfactory ensheathing cells（OECs）,a unique population of glia in the primary olfactory nervous system,are derived from the olfactory placode in the peripheral nervous system;they can envelop olfactory axons during migration from the olfactory epithelium to the bulb in the central nervous system and are thought critical for growth of olfactory axons in both the developing and adult olfactory nervous system.Importantly,OECs are potential candidates for implantation therapy of damage to the central nervous system.The biological features of OECs are determined by the molecules they express： PDGF,NDY,S-100,Nestin,etc.Although p75NTR is commonly used to label OECs,up to now there have been no specific molecules for identifying OECs from Schwann cells and astrocytes.This paper reviews the cellular and molecular biological properties of OECs.

关 键 词：嗅鞘细胞 生物学特性 分泌性蛋白 膜蛋白质类 胞质蛋白质类 

分 类 号：R329.481[医药卫生—人体解剖和组织胚胎学]