子痫前期胎盘抑制素A、胎盘激活素A和胎盘抑制素B基因的表达  

Expressions of Placenta Inhibin-A,Activin-A and Inhibin-B Genes in Preeclamptic Pregnancy

作　　者：董旭东[1] 吴云萍[2] 江江[2] 陈桂仙[2] 

机构地区：[1]云南省第一人民医院,云南昆明650032 [2]昆明医学院附属昆华医院,云南昆明650032

出　　处：《实用妇产科杂志》2011年第3期194-197,共4页Journal of Practical Obstetrics and Gynecology

基　　金：云南省中青年学术技术带头人后备人才资助项目(编号:2008PY045)

摘　　要：目的:探讨子痫前期患者胎盘中抑制素A(inhibin-A)、激活素A(activin-A)和抑制素B(inhibin-B)亚单位基因的表达水平及其意义。方法:采用逆转录聚合酶链反应(RT-PCR)技术定量测定44例子痫前期患者和30例正常妊娠妇女胎盘中inhibin-A、activin-A和inhibin-B亚单位基因mRNA的表达。结果:子痫前期组胎盘中inhibin-Aα-βA亚单位和activin-A βA-βA亚单位基因mRNA表达水平明显高于对照组,差异有统计学意义(P<0.05),而inhibin-B α-βB亚单位基因表达两组比较差异无统计学意义(P>0.05)。结论:子痫前期患者胎盘中的inhibin-A α-βA亚单位和activin-A βA-βA亚单位mRNA表达水平升高,inhibin-A/activin-A水平可反映滋养细胞的功能,是监测胎盘功能有效指标,并参与子痫前期的病理生理过程。Objective：To investigate the mRNA expression and the significance of inhibin-A,activin-A and inhibin-B subunites in the placenta from preeclamptic patients.Methods：The mRNA levels of inhibin-A,activin-A and inhibin-B subunites in the placenta from 44 pre-eclamptic patients and 30 normal pregnancies were measured by RT-PCR.Results：The mRNA levels of inhibin-A α-βA subunite and activin-A βA-βA subunite in the placentas from pre-eclamptic patients were significantly higher than those in the placenta from normal pregnancies（P〈0.05）,while the mRNA expression of inhibin-B α-βB subunit between the preeclamptic and normal pregnancy groups were no significant difference（P〈0.05）.Conclutions：The mRNA levels of inhibin-A α-βA subunite and activin-A βA-βA subunite increased significantly in the placenta from pre-eclamptic patients.The levels of inhibin-A and activin-A can reflect the function of trophoblastic cells,so they could be useful markers to monitor the function of placenta,and involve in the pathophysiologic process of preeclampsia.

关 键 词：子痫前期 胎盘 抑制素A 激活素A 抑制素B 

分 类 号：R714.244[医药卫生—妇产科学]