海洋真菌生物活性物质研究之管见  

A review on studies of secondary metabolites from marine fungi

作　　者：朱伟明[1] 王俊锋[1] 

机构地区：[1]海洋药物教育部重点实验室中国海洋大学医药学院,青岛266003

出　　处：《菌物学报》2011年第2期218-228,共11页Mycosystema

基　　金：国家"973"项目"海洋微生物次生代谢的生理生态效应及其生物合成机制"(No.2010CB83380);国家自然科学基金项目"嗜盐微生物抗肿瘤活性成分的研究"(No.30670219)

摘　　要：海洋真菌是活性海洋天然产物的重要来源,到目前为止,已从海洋真菌的发酵产物中分离鉴定了1,117个新化合物。介绍了海洋真菌次生代谢产物的研究历史、现状、特点、研究方法、存在问题及其在新药研究中的应用前景。Marine fungi are a kind of important source for active marine natural products.Up to now,1,117 new compounds have been isolated and identified from the fermentation broth of marine fungi.In this paper,the history,status quo,methods and issues in studying secondary metabolites from marine fungi are presented.The compounds originated from marine fungi and their perspective in drug discovery were also discussed.

关 键 词：海洋真菌 次生代谢 活性产物 含氮化合物 卤代物 

分 类 号：R282[医药卫生—中药学]