系统性红斑狼疮浆膜炎临床分析  

A clinical analysis on systemic lupus erythematosus associated with serositis

作　　者：丁翔[1] 孙凌云 张缪佳[3] 任义乐[1] 邵平[1] 

机构地区：[1]连云港市第一人民医院风湿免疫病科,222000 [2]南京市鼓楼医院风湿免疫病科 [3]南京医科大学附属第一医院风湿免疫病科

出　　处：《江苏医药》2011年第5期552-553,共2页Jiangsu Medical Journal

摘　　要：目的探讨系统性红斑狼疮(SLE)浆膜炎临床特点。方法回顾分析江苏省15家三级医院SLE住院患者1956例临床资料。结果浆膜炎组327例,发生率16.7%;非浆膜炎组1629例。浆膜炎组肾脏病变、血液异常发生率显著高于非浆膜炎组(63.9%vs.47.5%、66.4%vs.54.1%)(P<0.01);浆膜炎组颊部红斑、光过敏、关节炎发生率显著低于非浆膜炎组(40.1%vs.59.3%、11.9%vs.21.0%、49.2%vs.58.6%)(P<0.01);浆膜炎组SLE疾病活动评分及病死率显著高于非浆膜炎组[(14.1±6.3)分vs.(11.2±5.6)分、15.9%vs.6.9%](P<0.01)。结论 SLE浆膜炎并不少见,且易出现肾脏、血液等重要器官受累,病情较重,预后较差。Objective To investigate the features of systemic lupus erythematosus（SLE） associated with serositis.Methods Medical data of 1956 SLE inpatients from 15 grade Ⅲ hospitals in Jangsu province were retrospectively analyzed.Results Of 1956 SLE patients,327 cases were associated with serositis with an incidence rate of 16.7%.The positive rates of renal involvement and hematologic abnormality in serositis group were signifcantly higher than those in non-serositis group （63.9% vs.47.5% and 66.4% vs.54.1%）（P0.01）.The incidence rates of malar rash,photosensitivity and arthritis in serositis group were notably lower than those in non-serositis group（40.1% vs.59.3%,11.9% vs.21.0%,and 49.2% vs.58.6%）（P0.01）.The mean SLE disease activity index score and death rate in serositis group were strikingly higher than those in non-serositis group [（14.1±6.3）points vs.（11.2±5.6）points and 15.9% vs.6.9%]（P0.01）.ConclusionSerositis is not an uncommon complication of SLE.SLE patient with serositis often suffers from the injuries of critical organs such as kidney and blood with a poor condition and prognosis.

关 键 词：系统性红斑狼疮 浆膜炎 

分 类 号：R593[医药卫生—内科学]