疏血通对髋部骨科术后患者血浆TXB_2和6-Keto-PGF_(1α)水平的影响及其临床意义  

The Effect and Clinical Significance of Shuxuetong Injection on the Changes of Plasma TXB_2 and 6-Keto-PGF_(1α) Levels in Patients After Hip Orthopedic Operation

作　　者：毛兆光[1] 徐生根[1] 余斌伟[2] 徐尚敖[2] 郑逸华[3] 巫庆新[1] 朱慧华[1] 刘炳胜[1] 

机构地区：[1]浙江省江山市人民医院骨科,324100 [2]浙江省江山市人民医院检验科,324100 [3]浙江省江山市人民医院内科,324100

出　　处：《放射免疫学杂志》2011年第2期127-130,共4页Journal of Radioimmanology

基　　金：浙江省中医药科技计划项目(编号:2008CB076)基金资助

摘　　要：目的:探讨疏血通注射液对髋部骨科术后患者血栓素B2(TXB2)和6-酮-前列环素(6-Keto-PGF1α)水平变化的影响及其临床意义。方法:50例髋部骨科术后患者随机分为二组,均行常规基础治疗,疏血通组23例,其中7例髋关节置换(THR),16例髋部骨折内固定术,给予疏血通注射液6ml静脉滴注,每1次/d;低分子肝素钠组27例患者,其中9例髋关节置换(THR),18例髋部骨折内固定术,给予5000IU低分子肝素钠皮下注射,1次/d。两组疗程均为14d。手术日及疗程结束后清晨分别采集空腹静脉血,采用放射免疫分析患者血浆中TXB2和6-Keto-PGF1α的水平。两组患者均于术后第7d行下肢静脉造影检查。比较治疗前后两组患者TXB2、6-Keto-PGF1α的变化和下肢深静脉血栓形成(DVT)的发生率及其不良反应。结果:治疗前两组血浆TXB2、6-Keto-PGF1α含量的差别无统计学意义(P>0.05)。治疗后,疏血通组6-Keto-PGF1α升高和TXB2下降均有统计学意义(P<0.05);低分子肝素钠组6-Keto-PGF1α升高有统计学意义(P<0.01),TXB2变化无统计学意义(P>0.05);并且治疗后两组TXB2和6-Keto-PGF1α含量的差别均有统计学意义(P<0.05)。疏血通注射液组DVT总发生率为8.70%,低分子肝素组DVT总发生率为11.11%,两组相比差异无统计学意义(P>0.05)。两组均未发现术后出血增多等不良反应。结论:疏血通注射液可调节髋部骨科术后患者血浆TXB2/6-Keto-PGF1α的平衡,抑制血小板活化,可显著降低下肢深静脉血栓(DVT)的发生率,而且具有良好的安全性。Objective To investigate shuxuetong injection on the changes of thromboxane B2（TXB2） and 6-keto-prostacyclin（6-Keto-PGF1α） levels on the patients after hip orthopedic operation and its clinical significance.Methods 50 hip orthopedic surgery patients were randomly divided into the shuxuetong group and the low-molecular-weight heparin（LMWH） group.Both groups were treated with conventional therapy.Shuxuetong group were 23 cases,including 7 cases of total hip replacement（THR）,16 patients of internal fixation after hip fracture.Each patient were given Shuxuetong intravenous injection 6ml once a day,LMWH group contain 27 patients,including 9 cases of total hip replacement（THR）,18 patients of applying internal fixation to hip fracture.Each patient was given LMWH 5000 IU subcutaneously once daily.Both groups were treated for 14 days.In the day of surgery and the morning after therapy,fasting venous blood were collected respectively,The levels of plasma TXB2 and 6-Keto-PGF1α were measured by radioimmunoassay.Seven days after the surgery,patients in both groups were given low extremity venography examination.The changes of TXB2,6-Keto-PGF1α level and the incidence of lower extremity deep vein thrombosis（DVT） between two groups were compared before and after treatment.Results The levels of TXB2 and 6-Keto-PGF1α is not mach significant difference between the two groups before treatment（P0.05）.After treatment,the increased of 6-Keto-PGF1α and the decreased of TXB2 were statistically significant difference（P0.05） in the Shuxuetong group.6-Keto-PGF1α level of LMWH group was significantly higher after the treatment（P0.01）,and the change of TXB2 had no obvious difference（P0.05）.The levels of TXB2 and 6-Keto-PGF1α was significant difference between the two groups after treatment（P0.05）.The incidence of DVT in Shuxuetong injection group was 8.70%,and the incidence of DVT in LMWH group was 11.11%.There is no obvious difference between the two groups（P0.05）.Two groups were not fo

关 键 词：疏血通注射液 髋关节手术 血栓烷B2 6-酮-前列环素 深静脉血栓 

分 类 号：R562.25[医药卫生—呼吸系统]