慢性乙型肝炎患者SF、血清IGF-Ⅰ水平与脂质过氧化损伤的关系  

Relationship Between Serum SF,IGF-Ⅰ and Lipid Peroxidation Injury in Patients with Chronic Hepatitis B

作　　者：孟晓波[1] 

机构地区：[1]江苏省东海县人民医院检验科,222300

出　　处：《放射免疫学杂志》2011年第2期133-135,共3页Journal of Radioimmanology

摘　　要：目的:探讨了慢性乙型肝炎患者血清铁蛋白(SF)、胰岛素样生长因子-Ⅰ(IGF-Ⅰ)水平与脂质过氧化损伤的关系。方法:应用放射免疫分析和比色法对102例慢性乙型肝炎患者,进行了血清SF、IGF-Ⅰ和SOD、MDA检测,并与35名正常健康人比较。结果:各组慢性乙型肝炎患者血清SF、MDA水平非常显著地高于正常人组(P<0.01),而血清IGF-Ⅰ、SOD水平又非常显著地低于正常人组(P<0.01),血清SF水平与MDA水平呈正相关(r=0.6084,P<0.01),而与IGF-Ⅰ、SOD水平呈明显负相关(r=-0.4712、-0.5984,P<0.01)。结论:慢性乙型肝炎患者血清SF、IGF-Ⅰ与脂质过氧化有一定的相关性。Objective To explore the relationship between serum SF,IGF-Ⅰ and lipid peroxidation injury in patients with chronic hepatitis B.Methods Serum SF,IGF-Ⅰ（with RIA）.SOD,MDA（with chromatometry） levels were measured in 102 patients with chronic hepatitis B and 35 controls.Results Compared to control group,the levels of SF,MDA in patients with chronic hepatitis B were higher significantly（P0.01）,on the contrary,the levels of SOD,IGF-I in patients with chronic hepatitis B were lower significantly（P0.01）,in 102 patients with chronic hepatitis B,correlation analysis found that serum SF was in positive correlation with MDA（r=0.6084,P0.01） and SF was in negative correlation with IGF-Ⅰ,SOD（r=-0.4712,-0.5984,P0.01）.Conclusion The levels of SF,IGF-Ⅰ in patients with chronic hepatitis B are closely related to lipid peroxidation injury.

关 键 词：慢性乙型肝炎 铁蛋白 胰岛素样生长因子-Ⅰ 脂质过氧化 丙二醛 超氧化物歧化酶 

分 类 号：R512.62[医药卫生—内科学]