相分离法构建聚乳酸/纳米羟基磷灰石复合纳米纤维支架及性能  

Fabrication and Properties of Poly(L-Lactide)/Nano-Hydroxyapatite Composite Nano-Fibrous Scaffold by a Phase Separation Technique

作　　者：韩婉清[1] 屠美[1,2] 赵剑豪[1,2] 曾戎[1,2] 施云峰[3] 查振刚[4] 周长忍[1,2] 

机构地区：[1]暨南大学理工学院材料科学与工程系 [2]人工器官及材料教育部工程研究中心 [3]暨南大学分析测试中心 [4]暨南大学附属第一医院骨科,广东广州510632

出　　处：《高分子材料科学与工程》2011年第4期75-78,共4页Polymer Materials Science & Engineering

基　　金：国家科技部“863”资助项目(2007AA09Z440);国家自然科学基金资助项目(30900296)

摘　　要：通过液-液相分离法构建纳米纤维聚左旋乳酸/纳米羟基磷灰石(NF-PLLA/nHA)仿生复合支架,利用扫描电镜、压缩测试、微量二喹啉甲酸(BCA)法、X射线衍射及差示扫描量热等手段对其进行表征。结果显示,nHA均匀镶嵌在PLLA纳米纤维间隙中,不影响其纳米纤维结构且明显提高力学性能。同时,nHA的引入还能增加对牛血清白蛋白的吸附,PLLA的结晶度稍有下降,但结晶形态不变。因此,NF-PLLA/nHA复合支架有望成为优良的仿生骨组织工程支架。The composite nano-fibrous scaffold of poly（L-lactic acid）（PLLA） and nano-hydroxyapatite（nHA）,named as NF-PLLA/nHA,was prepared by a liquid-liquid phase separation technique.The properties of the scaffold were characterized by scanning electron microscopy,compression test,micro-Bicinchoninic acid（BCA） analysis,X-ray diffraction and differential scanning calorimetry,respectively.The results show that nHA uniformly distributes among PLLA nano-fibers without obvious effect on the PLLA nano-fibrous structure.The compressive modulus and the adsorption amount of the bovine serum albumin of NF-PLLA/nHA scaffold were distinctly improved by increasing nHA content,whereas the crystallinity of PLLA was somewhat reduced with unchangeable crystal form.Hence,the NF-PLLA/nHA scaffold will be a promising candidate for the bone tissue engineering.

关 键 词：聚左旋乳酸 纳米羟基磷灰石 相分离 纳米纤维支架 骨组织工程 

分 类 号：TB383[一般工业技术—材料科学与工程]