血清可溶性Fas与胎盘组织胎盘生长因子的表达在早发型重度子痫前期发病中的作用  

The role of expression of placental growth factor in placental and soluble Fas in serum in pathogenesis of early-onset of severe preeclampsia

作　　者：金峰[1] 乔宠[1] 尚涛[1] 

机构地区：[1]中国医科大学附属盛京医院妇产科,沈阳110004

出　　处：《中国免疫学杂志》2011年第4期335-336,341,共3页Chinese Journal of Immunology

摘　　要：目的:探讨血清可溶性Fas与胎盘组织胎盘生长因子在早发型重度子痫前期发病中的作用。方法:采用ELISA和免疫组化法分别检测20例早发重度子痫前期患者、35例晚发重度子痫前期患者和40例正常晚期妊娠患者血清可溶性Fas(Soluble Fas,sFas)和胎盘组织胎盘生长因子(placental growth factor,PlGF)的表达。结果:正常妊娠组、早发重度组、晚发重度组血清sFas水平分别为(1.17±0.53)、(6.68±0.97)和(3.17±0.74)mg/L,早发重度组、晚发重度组均显著高于正常对照组,差异有显著性(P<0.05)。早发重度组又明显高于晚发重度组,差异有显著性。正常妊娠组胎盘组织PlGF表达的平均灰度值显著高于早发型及晚发型重度子痫前期组,其中早发型子痫前期重度组表达最低。早发重度组中血清sFas与PlGF呈负相关,相关系数-0.748。结论:重度子痫前期患者血清sFas表达升高,且早发重度组表达显著高于晚发重度组,并与PlGF呈负相关,说明其异常表达可能是早发重度子痫前期发病的主要原因。Objective： To investigate the role of soluble Fas in serum and placental growth factor in placenta in the pathogenesis of ear- ly-onset of severe preeclampsia. Methods： Fifty-five patients with Severe preeclampsia and forty healthy pregnant women were studied and both the se^m samples of serum and placenta were collected. The expression of placental growth factor in placenta was determined by immunohisto- chemisty and the concentration of soluble Fas in serum was detected with ELISA method. Results： Serum levels of soluble Fas in early-onset of severe preeclampsia group were significantly higher than those of late-onset severe preeclampsia and healthy pregnant woman. The expression of P1GF in placenta was decreased in early-onset of severe preeclampsia, and it was shown in a negatively correlation with sFas. Conclusion： There is an increasing expression of sFas in early-onset of severe preeclampsia than in the late-onset of severe preeclampsia. It is correlated with low expression of PIGF that means low invasive ability of trophoblast, sFas may play an important role in the pathogenesis of the disease.

关 键 词：子痫前期 早发型 胎盘 膜蛋白类 胎盘生长因子 

分 类 号：R714.246[医药卫生—妇产科学]