因卡膦酸二钠治疗骨质疏松症的临床研究  

Effect of incadronate on various osteoporosis

作　　者：兰培丽[1] 孟凌新[1] 

机构地区：[1]中国医科大学附属盛京医院疼痛科,沈阳110004

出　　处：《实用药物与临床》2011年第2期123-125,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨因卡膦酸二钠治疗骨质疏松症的临床疗效。方法选择86例各种原因致骨质疏松症患者,随机分为治疗组与对照组,每组43例。治疗组给予因卡膦酸二钠5～10 mg+0.9%氯化钠注射液500 mL缓慢静滴,超过3 h,每4周1次,连续3～4个月为1个疗程;对照组给予钙尔奇的片,每日三餐进食前半小时温开水送服,每日1次。观察患者用药后15 d、1个月、3个月临床症状改善情况、腰椎骨密度测定及检测(BMD)、VAS评分、睡眠质量评分的改善情况。结果因卡膦酸二钠较钙尔奇的片能明显提高患者腰椎骨密度(P<0.05),VAS评分随时间减少,睡眠质量明显提高,并减少骨折的发生。结论因卡膦酸二钠治疗骨质疏松及其所致疼痛疗效显著。Objective To investigate the clinical efficacy and safety of incadronate on patients with pain of various osteoporosis. Methods A randomized,parallel comparative trial was performed on 86 patients with pain of various osteoporosis.The patients were randomized into test group（incadronate 5～10 mg ＋ 0.9%sodium chloride injection 500 mL,iv,3 h） and control group（Calcium Welch 90 mg,tid,po）.The efficacy and the alleviated status of incadronate and Calcium Welch were observed at 15 d,1 month,3 month after treatment. Results Visual analogue scales（VAS） was considerably declined and QS scales decreased.There were significant differences between the two groups in pain relief and VAS improvement. Conclusion Incadornate is an effective drug in the treatment of patients with various osteoporosis.

关 键 词：骨质疏松症 因卡膦酸二钠 

分 类 号：R580[医药卫生—内分泌]