中间体2,4-二羟基苯乙酮合成工艺研究  

Synthesis of Intermediate 2,4-dihydroxy Acetophenone

作　　者：曹晓燕[1] 刘小风[1] 王建国[1] 

机构地区：[1]九江学院化学化工学院,江西九江332005

出　　处：《广州化工》2011年第8期87-89,共3页GuangZhou Chemical Industry

摘　　要：介绍了合成2,4-二羟基苯乙酮的工艺路线:在催化剂的作用下,由原料间苯二酚和冰醋酸经付-克反应合成2,4-二羟基苯乙酮。最佳反应条件为:冰醋酸用量12 g、催化剂用量16 g、反应时间1.5 h、反应温度135℃。产品经紫外、红外、熔点和Rf值鉴定为2,4-二羟基苯乙酮。By way of Friedel-Crafts reaction,carrying out resorcinol and acetic acid as raw materials,the synthesis technology of 2,4-dihydroxyacetophenone was studied.At the same time,with the parameter of yield ratio and single factor experiment,the highest conversion was achieved when the amount of acetic acid was 12 g with addition of 16 g catalyst and reacted at 135 ℃ for 1.5 h.The product was identified to be 2,4-dihydroxyacetophenone by UV,IR,melt point and Rf value.

关 键 词：2 4-二羟基苯乙酮 合成 表征 

分 类 号：TQ463.4[化学工程—制药化工]