曲美他嗪对缺血性心力衰竭大鼠心脏功能与氧自由基代谢的影响  

Effects of Trimetazidine on Cardiac Function and free radical metabolism in Rats with Ischemic Heart Failure

作　　者：马丕勇[1] 李佳彧[2] 杨萍[2] 

机构地区：[1]吉林大学中日联谊医院急救医学科,吉林长春130033 [2]吉林大学中日联谊医院心内科,吉林长春130033

出　　处：《中国实验诊断学》2011年第4期614-616,共3页Chinese Journal of Laboratory Diagnosis

基　　金：国家自然科学基金资助项目(No:30770883)

摘　　要：目的探讨曲美他嗪对缺血性心力衰竭大鼠心脏功能的影响,其作用与给药时间的关系。方法采用结扎左冠状动脉的方法,建立缺血性心力衰竭大鼠模型,对两组模型大鼠分别于术后24小时内及术后4周,给予曲美他嗪干预,与术后8周观察心脏指数、血流动力学改变,与假手术组及心衰对照组比较,同时比较SOD、MDA的改变。结果药物干预治疗的大鼠在心脏指数、血流动力学方面相比心衰组均有明显改善,并可以显著升高SOD活性,降低MDA水平,术后24小时应用曲美他嗪组改善更明显。结论曲美他嗪可以明显改善缺血性心力衰竭大鼠心脏功能,且早期应用效果更加明显。Objective To investigate the effects of trimetazidine on cardiac function in rats with ischemic heart failure.Methods We established ischemic heart failure rats by the left coronary artery ligation.30 rats after operation were separated randomized into 3 groups.Trimetazidine was given intervention within 24 hours after surgery in one group（TI group） and after 4 weeks in another group（TF group）.The 3rd group was heart failure control group（F group）.After 8 weeks we observed the cardiac index,hemodynamic changes of each groups compared with the sham group（S group）,and SOD,MDA changes in each groups.Results Trimetazidine was significantly improved cardiac function compared to F group.and significantly aggrandized the activity of SOD,reduced content of MDA（P0.01）.The improvement was more significant in TI group.Conclusion Trimetazidine can improve heart function in rats with ischemic heart failure,and the effect is more obvious in early stage.

关 键 词：曲美他嗪 心力衰竭 心脏功能 

分 类 号：R541.6[医药卫生—心血管疾病]