职业性慢性铅中毒患者CD8低表达T淋巴细胞数量观察  

Abnormal increase in CD8lowT lymphocyte in patients with occupational chronic lead poisoning

作　　者：余卫[1] 罗英[1] 陈嘉榆[1] 刘薇薇[1] 陈玲珍[1] 巫进民[1] 詹昱[1] 李箔[2] 李扬秋[2] 

机构地区：[1]广州市第十二人民医院内一科,510620 [2]暨南大学医学院血液病研究所

出　　处：《中华劳动卫生职业病杂志》2011年第3期222-223,共2页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：广州市医药卫生科技一般引导项目（2009-YB-115）

摘　　要：目的通过分析外周血T淋巴细胞CD8分子表达水平，了解职业性慢性铅中毒患者异常的免疫功能状态。方法对23例职业性慢性铅中毒患者（铅中毒组）及20例健康非职业铅接触成人（对照组）采用流式细胞技术检测外周血T淋巴细胞CD8分子表达水平，统计CD8低表达（CD8h）细胞群和正常表达（CD8norrnal）细胞群的数量。结果与对照组（8．21％±3．02％）比较，铅中毒组CD8low细胞群相对百分比（12．98％±5．62％）明显增加，差异有统计学意义（P〈0．05）；两组CD8norrnal细胞群数量则无明显变化。结论职业性慢性铅中毒患者外周血CD8＋T淋巴细胞虽然总数没有异常，但CD8分子表达出现了弱化。该现象可能是铅致免疫功能损伤重要表现之一，CD8low细胞群有望成为研究铅免疫毒性新的线索。Objective To analyze the changes in CD8low T lymphocyte subsets in patients with occupational chronic lead poisoning. Methods Flow cytometric analysis was used to count the numbers of CD8 ± ceils. 23 patients with occupational chronic lead poisoning and 20 controls were examined. Results Compared with control group （8.21%±3.02%）, the CD8low T lymphocyte （12.98%±5.62%） were significantly increased in patients with occupational chronic lead poisoning. Conclusion Although the ratio of CD ＋T lymphocyte is normal, the CD8 level is significantly decreased. The increase of CD81~ T lymphocyte may be an important phenomenon of immuno-injury induced by lead. CD8low T lymphocyte could be an new direction for research of lead immnnn-toxicity.

关 键 词：铅 T淋巴细胞亚群 免疫系统 

分 类 号：R1[医药卫生—公共卫生与预防医学]