(Z,E)-1-[1-(2,4-二氧吡咯烷-3-亚基)乙基]-4-烃基氨基脲类衍生物的合成与除草活性  

Synthesis and Herbicidal Activities of(Z,E)-1-[1-(2,4-Dioxo-pyrrolidine-3-ylidene)ethyl]-4-alkylsemicarbazide Derivatives

作　　者：司腾飞[1,2] 孟范贵[2] 王先锋[2] 朱兆勇[1] 强胜[3] 杨春龙[1,2] 

机构地区：[1]南京农业大学江苏省农药学重点实验室,南京210095 [2]南京农业大学农业部病虫监测与防控重点开放实验室,南京210095 [3]南京农业大学生命科学学院,南京210095

出　　处：《有机化学》2011年第4期521-527,共7页Chinese Journal of Organic Chemistry

基　　金：国家高技术研究发展计划(863计划)(No.2006AA10A214);中央高校基本科研业务费专项资金资助项目

摘　　要：以取代胺为原料合成6种N^4-取代氨基脲,然后与5种3-(1-羟基亚乙基)-吡咯烷-2,4-二酮类化合物反应合成了22种新型缩氨基脲类衍生物,即(Z,E)-1-[1-(2,4-二氧吡咯烷-3-亚基)乙基]-4-烃基氨基脲,其结构经~1H NMR,MS,IR和元素分析确证.初步生物活性测定表明,这类化合物对油菜根和稗草茎的生长具有抑制作用.Six N^4-substituted semicarbazides, which were synthesized using substituted amines as starting material, were reacted with five 3-（1-hydroxyethylidene）pyrrolidine-2,4-diones to give twenty two novel （Z,E）-1-[1-（2,4-dioxo-pyrrolidine-3-ylidene）ethyl]-4-alkylsemicarbazide derivatives. The structures of the target compounds were confirmed by ^1H NMR, MS, IR techniques and elemental analysis. The preliminary bioassay results indicated that these compounds exhibited certain inhibitive activities against the root of Brassica napus and the stalk of Echinochloa crusgalli.

关 键 词：缩氨基脲 吡咯烷 合成 除草活性 

分 类 号：TQ450.1[化学工程—农药化工]