基质金属蛋白酶诱导因子和白三烯B_4在急性冠状动脉综合征中表达  

Expression of extracellularmatrix metalloproteinase inducer and leukotriene B_4 in patient with acute coronary syndrome

作　　者：许莎莎[1] 黄洁[1] 江建军[1] 王教辰[2] 米亚非[1] 刘志国[1] 卢先本[1] 薛迎生[1] 葛卫力[1] 王琳[1] 陈保国[3] 朱敏[3] 黄维清[4] 唐礼江[1] 

机构地区：[1]温州医学院附属台州医院心内科 [2]温州医学院附属台州医院病理科 [3]温州医学院附属台州医院中心实验室 [4]山东省青岛市市立医院东院病理科

出　　处：《临床心血管病杂志》2011年第3期220-222,共3页Journal of Clinical Cardiology

基　　金：浙江省科技厅基金资助(No:2006c33019)

摘　　要：目的:研究基质金属蛋白酶诱导因子(EMMPRIN)及白三烯B4(LTB4)在急性冠状动脉综合征中表达。方法:设立稳定型心绞痛组(SAP组)、不稳定型心绞痛组(UAP组)、急性心肌梗死组(AMI组)及对照组(CON组),以流式细胞计数法测定患者外周静脉血单核细胞表面EMMPRIN表达,ELISA法检测其血清LTB4水平。结果:EMMPRIN在UAP组显著高于CON组、SAP组、AMI组,在UAP<1周亚组表达明显。LTB4在AMI组显著高于CON、SAP和UAP组,其AMI<24h亚组增高显著。结论:UAP患者外周血单核细胞表面EMMPRIN表达增高,其出现高峰为胸痛1周内;AMI患者血清中LTB4表达上调,高峰为胸痛24h之内。Objective：To study the expression of extracellularmatrix metalloproteinase inducer（EMMPRIN） and leukotriene B4（LTB4） in patient with acute coronary syndrome（ACS）.Method：There were four groups in this study,including SAP,UAP,AMI,and CON group.The expression of EMMPRIN on peripheral blood mononuclear cells were determined by flow cytometry,while LTB4 level in serum was measured by ELISA.Result：The expression of EMMPRIN in UAP patients was significantly higher than that in CON,SAP and AMI groups,especially in 1 week.The level of LTB4 in AMI group was higher than the other three groups,especially in 24 hours.Conclusion：EMMPRIN on peripheral blood mononuclear cells increased significantly in UAP patients with the peak in 1 week.Serum LTB4 increased in AMI patients with the peak in 24 hours.

关 键 词：急性冠状动脉综合征 细胞外基质金属蛋白酶诱导剂 白三烯B4 

分 类 号：R541.4[医药卫生—心血管疾病]