冠通活瘀胶囊对大鼠急性心肌缺血的保护作用  

Protective efficacy of Guanxinhuoyu Capsule in rats with acute myocardium ischemia

作　　者：宋亚娟[1] 王欣[1] 张丹丹[1] 王伟明[1] 许庆瑞[1] 张树明[1] 张俊威[1] 

机构地区：[1]黑龙江省中医研究院中药所药理室

出　　处：《中国临床药理学与治疗学》2011年第1期42-45,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:观察冠通活瘀胶囊对小鼠注射异丙肾上腺素(ISO)后耐缺氧存活时间和注射垂体后叶素(Pit)所致的心肌缺血的影响。方法:采用腹腔注射ISO后观察小鼠耐缺氧存活时间和尾静脉注射Pit致大鼠急性心肌缺血模型,观察各给药组在腹腔注射ISO后耐缺氧存活时间和注射Pit后不同时间点Ⅱ导心电图T波变化百分率,心率变化及对血清肌酸激酶(CK)、乳酸脱氢酶(LDH)和谷草转氨酶(AST)的影响。结果:冠通活瘀胶囊低、中剂量组与模型组比较,均能明显延长小鼠耐缺氧存活时间和降低心肌缺血大鼠心电图T波峰值变化百分率(P<0.05);与注射Pit前比较,能对抗Pit致心率减慢的损伤,并能显著降低血清中CK、LDH和AST的含量。结论:冠通活瘀胶囊具有降低小鼠心肌耗氧量和抗Pit引起的大鼠急性心肌缺血作用。AIM ： To investigate the effect of Guanxinhuoyu Capsule against hypoxia after injection of isoproterenol and in rats with acute myocardial ischemia induced by pituitary. METHODS ： The anti-hypoxia model was established by injection of isoproterenol and the acute myocardium ischemia rat model was established by caudal venous injection of pituitrin.The survival time and the changes of the T wave in lead II ECG and heart rate were observed. RESULTS ：Guanxinhuoyu Capsule for low and medium dose groups compare with model group,could significantly prolong the survival time by isoproterenol in mice and significantly lower the percentage change of T wave inhibit slowed heart rate induced by pituitrin in rats,and notably decrease the levels of CK,LDH and AST. CONCLUSION ： Guanxinhuoyu Capsule reduces myocardial-oxygen consumption and anti-myocardial ischemia effect in rats with acute myocardium ischemia induced by pituitary.

关 键 词：冠通活瘀胶囊 垂体后叶素 心肌缺血 心电图 耐缺氧 

分 类 号：R965.2[医药卫生—药理学]