不同时间给予比索洛尔对非杓型原发性高血压患者肾素-血管紧张素-醛固酮系统的影响  

Effects of bisoprolol with different drug administration time on the renin-angiotension-aldosterone system of non-dippers hypertension

作　　者：刘华强[1] 闫美兴[1] 王少华[1] 孙晓蕾[2] 

机构地区：[1]青岛市市立医院药学部 [2]青岛大学医学院

出　　处：《中国临床药理学与治疗学》2011年第1期101-104,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：山东省卫生厅立项课题(2007hw005)

摘　　要：目的:探讨不同时间给予比索洛尔对非杓型原发性高血压患者肾素-血管紧张素-醛固酮系统(RAAS)的影响。方法:选择非杓型原发性高血压病患者60例,采取随机平行对照试验,观察比索洛尔每日早晨(8?00)给药2.5～10 mg、比索洛尔每日夜间(20?00)给药2.5～10 mg治疗8周前后分别检测血浆肾素(Ren)、血管紧张素Ⅱ(AngⅡ)、醛固酮(Ald)浓度并进行分析评价。结果:治疗后上述各指标较治疗前均明显降低,差异有统计学意义(P<0.05)。两组间比较肾素指标无统计学差异(P>0.05),血管紧张素Ⅱ、醛固酮指标有统计学差异(P<0.05)。结论:早晨或夜间服用比索洛尔均能降低患者肾素、血管紧张素Ⅱ和醛固酮浓度,晚上服用比索洛尔对血管紧张素Ⅱ和醛固酮的影响更为显著。AIM ： To explore effect of renin-angiotension-aldosterone system induced by bisoprolol with different time drug administration in patients with non-dipper hypertension. METHODS ： The patients were randomly divided into two parallel groups.All patients were treated with bisoprolol.The first group were received bisoprolol at eight o＇clock once-daily between 2.5 mg and 10 mg.The second group were received bisoprolol at twenty o＇clock once-daily between 2.5 mg and 10 mg.The concentration of rennin,angiotension and aldosterone after 8 weeks＇ treatment were detected and evaluated. RESULTS ：The concentration of rennin,angiotension and aldosterone after treatment were lower than before treatment in two groups（P 0.05）.And there was no significant difference between two groups on the concentration of renin（P 0.05）,but a significant difference on angiotension and aldosterone（P 0.05）. CONCLUSION ： Two methods of treatment can decrease the concentration of rennin,angiotension and aldosterone,but the non-dippers hypertension taked drug at eight o＇clock has a signifcant effect on angiotension and aldosterone.

关 键 词：比索洛尔 非杓型高血压 肾素-血管紧张素-醛固酮系统 

分 类 号：R544.1[医药卫生—心血管疾病]