5-羟色胺受体拮抗剂在肺动脉高压防治中的应用与展望  

Application and prospects of 5-HT receptor antagonists in the prevention and treatment of pulmonary hypertension

作　　者：肖雄[1] 侯颖[1] 李小强[1] 

机构地区：[1]第四军医大学药学系药理学教研室

出　　处：《中国临床药理学与治疗学》2011年第1期111-115,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金(30800433)

摘　　要：肺动脉高压是一组由多种病因和发病机制引起的以肺血管阻力进行性增加为特征的病理生理综合征。临床表现为右心室功能不全,预后不良,严重者可发生右心衰竭而死亡。本文主要综述了5-羟色胺与肺动脉高压的关系及5-羟色胺受体拮抗剂在肺动脉高压防治中的作用,展望了5-羟色胺受体拮抗剂可能是一类有潜力的新型治疗肺动脉高压的药物。Pulmonary hypertension is a group of clinical pathophysiological syndrome characterized by increased pulmonary vascular resistance due to multiple etiologies and pathogenesis.The main clinical manifestations are right ventricular dysfunction with poor prognosis,and patient of severe right heart failure can even cause death.This article reviews the relationship between the 5-HT and pulmonary hypertension,and the 5-HT receptor antagonists＇ effects on the prevention and treatment of pulmonary hypertension.The article also prospects that 5-HT receptor antagonists may be a kind of very promising new drugs in the treatment of pulmonary hypertension.

关 键 词：5-羟色胺 5-羟色胺受体 拮抗剂 肺动脉高压 

分 类 号：R543.2[医药卫生—心血管疾病]