Correlation between LRRK2 gene polymorphism sites S1647T and R1398H and Parkinson’s disease in a Chinese Han population  

作　　者：Xueli Chang Xueye Mao Zijuan Zhang Jinhong Zhang Yuan Yang Tao Li Nannan Li Jean-Marc Burgunder Rong Peng 

机构地区：[1]Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China [2]Department of Neurology, Tianjin First Center Hospital, Tianjin 300192, China [3]Department of Internal Medicine, Wangjiang Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China [4]Department of Genetics, West China Hospital, Sich uan University, Chengdu 610041, Sichuan Province, China [5]Department of Psychiatry, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China [6]Department of Neurology, University of Bern, Bern 999034, Switzerland

出　　处：《Neural Regeneration Research》2011年第5期340-345,共6页中国神经再生研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China, No. 30870846

摘　　要：A recent multicenter study demonstrated that two variants of LRRK2, S1647T and R1398H, are associated with sporadic Parkinson＇s disease. The present study analyzed LRRK2 gene polymorphisms of S1647T and R1398H, demonstrating that the LRRK2 gene polymorphism S1647T variant is a risk factor for Parkinson＇s disease in a Chinese Han population. However, the R1398H variant did not influence the risk for Parkinson＇s disease. In addition, there was no difference in clinical symptoms of Parkinson＇s disease patients with various genotypes. Results showed that the LRRK2 S1647T variant was associated with an increased risk for developing early-onset Parkinson＇s disease in a Chinese Hart population. In addition, there was no correlation between LRRK2 S1647T, R1398H variants and G2385R, R1628P variants in Parkinson＇s disease patients.A recent multicenter study demonstrated that two variants of LRRK2, S1647T and R1398H, are associated with sporadic Parkinson＇s disease. The present study analyzed LRRK2 gene polymorphisms of S1647T and R1398H, demonstrating that the LRRK2 gene polymorphism S1647T variant is a risk factor for Parkinson＇s disease in a Chinese Han population. However, the R1398H variant did not influence the risk for Parkinson＇s disease. In addition, there was no difference in clinical symptoms of Parkinson＇s disease patients with various genotypes. Results showed that the LRRK2 S1647T variant was associated with an increased risk for developing early-onset Parkinson＇s disease in a Chinese Hart population. In addition, there was no correlation between LRRK2 S1647T, R1398H variants and G2385R, R1628P variants in Parkinson＇s disease patients.

关 键 词：LRRK2 S1647T R1398H Parkinson＇s disease neural regeneration 

分 类 号：Q347[生物学—遗传学] TQ46[化学工程—制药化工]