Unexpected 1,3-Dipolar Cycloaddition Reaction of Thiazolo[3,2-a]pyrimidine Derivatives and Nitrilimine  

作　　者：李筱芳 刘浩冲 刘彬 郑爱庭 李国斌 于贤勇 易平贵 

机构地区：[1]Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, Hunan Province College Key Laboratory of QSAR/QSPR, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201, China

出　　处：《Chinese Journal of Chemistry》2011年第4期741-744,共4页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （Nos. 20971041, 20803020, 20772027）, Chinese Ministry of Education （No. 210146） and Scientific Research Fund of Hunan Provincial Education Department （Nos. 09B032, 09C385, 09K081）.

摘　　要：The 1,3-dipolar cycloaddition reactions of nitrilimine with thiazolo[3,2-a]pyrimidine derivatives was investigated. Bis-cycloadducts were obtained through a domino 1,3-dipolar cycloaddition/ring-opening/ring-opening/ 1,3-dipolar cycloaddition processes. The structures of the products were characterized thoroughly by NMR, IR, MS, elemental analysis together with X-ray crystallographic analysis.The 1,3-dipolar cycloaddition reactions of nitrilimine with thiazolo[3,2-a]pyrimidine derivatives was investigated. Bis-cycloadducts were obtained through a domino 1,3-dipolar cycloaddition/ring-opening/ring-opening/ 1,3-dipolar cycloaddition processes. The structures of the products were characterized thoroughly by NMR, IR, MS, elemental analysis together with X-ray crystallographic analysis.

关 键 词：1 3-dipolar cycloaddition thiazolo[3 2-a]pyrimidine NITRILIMINE reaction mechanism SYNTHESIS 

分 类 号：TQ252.1[化学工程—有机化工] S831.5[农业科学—畜牧学]