超声评价通心络胶囊对代谢综合征患者血管内皮功能的作用  

Ultrasound evaluation effects of Tongxinluo Capsule on vascular endothelial function in patients with metabolic sysdrome

作　　者：赵学兰[1] 李香玲[1] 张琳琳[1] 马桂凤[2] 

机构地区：[1]潍坊医学院附属医院肾内科,山东潍坊261031 [2]潍坊医学院附属医院影像中心,山东潍坊261031

出　　处：《中国现代医学杂志》2011年第8期1040-1042,共3页China Journal of Modern Medicine

基　　金：潍坊市科学技术发展计划项目(No:200902074)

摘　　要：目的用高频超声评价通心络胶囊对代谢综合征(MS)患者肱动脉血流介导的舒张功能的保护作用。方法用通心络胶囊治疗MS患者43例,疗程6个月,采用高频超声分别检测基础状态(D0)、反应性充血状态(D1)、含服硝酸甘油3￣5 min时(D2)肱动脉内径的变化。结果通心络胶囊对MS患者肱动脉血流介导的内皮依赖性舒张功能(EDD)治疗后较治疗前明显改善(P<0.01);而硝酸甘油介导的非内皮依赖性舒张功能(ED)治疗前后无差异(P>0.05)。结论通心络胶囊能有效改善MS患者的EDD;高频超声可用于MS患者EDD的检测及药物疗效的评估。【Objective】 To investigate the improving effect of Tongxinluo Capsule on the brachial artery flow-mediated diastolic function in patients with metabolic syndrome（MS） by high-frequency ultrasonography.【Methods】 43 cases of MS were treated with Tongxinluo Capsule for 6 months,and the changes of the diameter of brachial artery during baseline（D0）,reactive hyperemia（D1） and taking nitroglycerin for 3~5 minutes（D2） were examined by high-frequency ultrasonography.【Results】 After treatment of Tongxinluo capsule,MS patients with brachial artery flow-mediated endothelium-dependent vasodilation（EDD） significantly improved（P 0.01）.There was no significant difference in the nitroglycerin-mediated endothelium-dependent vasodilation（ED） after the therapy（P 0.05）.【Conclusion】 Tongxinluo capsule can significantly improve EDD of MS patients,and high-frequency ultrasonography can be used to detect the EDD and assess the effect of drugs for MS patients.

关 键 词：代谢综合征 通心络胶囊 内皮功能 超声检查 

分 类 号：R287[医药卫生—中药学] R589[医药卫生—中医学]