基于质谱检测的相关色谱技术在阿尔茨海默病诊断中的应用  

Application of mass spectrometry-based chromatographic technologies in the diagnosis of Alzheimer's disease

作　　者：王鼎乾[1] 辛贵忠[1] 石子琪[1] 陈君[1] 李萍[1] 

机构地区：[1]现代中药教育部重点实验室中国药科大学生药学教研室,江苏南京210009

出　　处：《色谱》2011年第4期293-297,共5页Chinese Journal of Chromatography

基　　金："十一五"国家"重大新药创制"科技重大专项(No.2009ZX09502-020);国家自然科学基金面上项目(No.81073006)

摘　　要：随着世界老年人口的急速增长,阿尔茨海默病发病人数也逐年增多,已成为继心脑血管疾病和恶性肿瘤之后威胁人类健康的"第三大杀手"。疾病的诊断和治疗同等重要,阿尔茨海默病诊断通常依靠典型的临床特征、神经影像技术以及检测疾病相关的生物标志物等。近些年来蛋白质组学和质谱技术迅速发展,可以利用这些技术寻找到与疾病相关的特异性的蛋白质分子作为早期诊断的生物标志物。本文就此进行了综述,主要包括基于蛋白质组学的诊断标志物的筛选和基于质谱检测的色谱技术在阿尔茨海默病诊断中的应用,引用文献34篇。With the rapid growth of the elderly population in the world,the incident number of Alzheimer＇s disease（AD） is also increasing year by year.AD has become ＂the third biggest killer＂ to human health besides cardiovascular and cerebrovascular diseases and cancers.The diagnosis and treatment of diseases are of equally significance.Generally,the diagnosis of AD relies upon the typical clinical features,neuroimaging techniques,and the detection of disease-related biomarkers.In recent years,proteomics and mass spectrometry technology have developed rapidly,which can be used to find specific disease-related proteins as biomarkers for early diagnosis.This review focused on the proteomics-based screening of diagnostic biomarkers and the mass spectrometry-based chromatographic technologies applied in the diagnosis of AD.34 references are reviewed.

关 键 词：质谱 色谱技术 阿尔茨海默病 生物标志物 

分 类 号：O658[理学—分析化学]