持续气道正压通气对老年OSAHS合并2型糖尿病患者胰岛素抵抗的影响  

Effect of Continuous Positive Airway on Insulin Resistance in Elderly Patients with Type 2 Diabetes and OSAHS

作　　者：江宏志[1] 郭冠芬[1] 张平[1] 周柳如[1] 

机构地区：[1]广东省东莞市人民医院呼吸内科,广东东莞523000

出　　处：《医学临床研究》2011年第3期493-495,共3页Journal of Clinical Research

摘　　要：[目的]探讨持续气道正压通气（CPAP）对老年合并2型糖尿病的阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者胰岛素抵抗（IR）的影响.[方法]选择老年合并2型糖尿病的OSAHS患者52例,通过3个月的CPAP治疗,观察治疗前后反映IR的稳态模式评估（HOMA）指数变化.[结果]CPAP治疗3个月后呼吸暂停/低通气指数（AHI）及最低脉搏血氧饱和度（SpO2）（miniSpO2）较治疗前明显改善（P〈0.01）, HOMA指数较治疗前明显降低（3.62±0.86 vs 1.98±0.78,P〈0.01）.[结论]CPAP治疗可显著改善老年合并2型糖尿病的OSAHS患者的IR.[Objective]To explore the effect of continuous positive airway pressure（CPAP） on insulin resist ance（IR） in elderly patients with type 2 diabetes and obstructive sleep apnea hypopnea syndrome（OSAHS）. [Methods] Fifty-two elderly patients with type 2 diabetes and OSAHS were enrolled in this study. All patients received CPAP treatment for 3 months. The change of homeostasis model assessment（HOMA） index reflecting IR was observed before and after treatment. [Results] After 3 months of CPAP treatment, the apnea/hypopnea index （AHI） and miniSpO2 were improved significantly compared with that before treatment（ P 〈0.01）. The HOMA index was significantly decreased after 3 months of CPAP treatment compared with that before treatment（3.62±0.86 vs 1.98±0.78, P 〈0.01）. [Conclusion]CPAP treatment can significantly improve the IR in elderly patients with type 2 diabetes and OSAHS.

关 键 词：睡眠呼吸暂停综合征/并发症 糖尿病 非胰岛素依赖型/并发症 正压呼吸 

分 类 号：R563.8[医药卫生—呼吸系统]