四苯硼钠法测定吡哌酸含量  

Determination Pipemidic Acid by Sodium Tetraphenylborate Method

作　　者：魏文珑[1] 李彦威[1] 王晋辉[2] 

机构地区：[1]太原理工大学化学工程与技术学院,太原030024 [2]山西大学校医院,太原030006

出　　处：《分析化学》1999年第12期1405-1407,共3页Chinese Journal of Analytical Chemistry

摘　　要：介绍一种测定吡哌酸含量的有效方法.在pH=3.6的HAc-NaAc缓冲溶液中,吡哌酸与四苯硼钠可形成1:1的定量沉淀,待沉淀反应完全后,以溴酚蓝为指示剂,用烃铵盐标准溶液回滴过量的四苯硼钠,方法简便、快速,应用于吡哌酸原料药样品测定,其回收率为99.44%～100.09%,最大相对误差<±0.6%,与药典法测得的结果基本一致.This paper describes an effective method for determining pipemidic acid(PPA) . The excess of sodium tetraphenylborate (Na-TPB) was added to precipitated PPA in HAc-NaAc buffer solution (pH = 3.6). After filtering off part of the mixture, the excess of TPB in the filtrate was titrated with alkyl ammaoium salts standard solution, and bromphenol blue as indicator. This method is simple and rapid, it has been applied to the determination of PPA raw materials with satisfactory results. The recovery wasfrom 99.44% to 100.09% and the relative error was less than ±0.60% .

关 键 词：吡哌酸 四苯硼钠 烃铵盐 溴酚蓝 滴定法 回收率 

分 类 号：O655.2[理学—分析化学] R978.5[理学—化学]