云克（99Tc-MDP）对亚急性衰老小鼠肝脏抗氧化作用的影响  

Effects of Yunke（99Tc-MDP） on Subacute Aging Mice＇s Liver Antioxidant Indexes

作　　者：薛秀青[1] 张彦军[2] 黄赛男[2] 苏成海[1] 

机构地区：[1]苏州大学附属第一医院核医学科,江苏苏州215006 [2]苏州大学医学部免疫教研室,江苏苏州215123

出　　处：《中国血液流变学杂志》2011年第1期4-6,共3页Chinese Journal of Hemorheology

基　　金：国家自然科学基金（30970714）;江苏省自然科学基金（BK2010252）

摘　　要：目的 研究云克对D-半乳糖亚急性衰老小鼠模型肝脏抗氧化指标的影响.方法 健康雌性昆明种小鼠48只,随机分为6组：正常空白对照组、模型组、维生素E组、云克低、中、高剂量组.给药6周后脱臼处死,取出肝脏,制成肝脏组织匀浆液,测定其对肝脏中的SOD（超氧化物歧化酶）、MDA（丙二醛）、GSH-PX（谷胱甘肽过氧化物酶）、MAO（单胺氧化酶）的影响.结果 云克能显著提高衰老小鼠肝脏SOD、GSH-PX的活性,降低衰老小鼠肝脏中MDA、MAO的含量,云克组、维生素E组之间无统计学意义.结论 云克能保护机体免受自由基的损伤,进而发挥抗氧化作用及延缓衰老.Objective To verify whether yunke（Technetium [99Tc] Methylenediphosphonate Injection;99Tc- MDP） has the effect of anti-aging by observing the change of subacute aging mice＇ liver antioxidant indexes. Methods 48 healthy female Kunming mice were randomly divided into 6 groups：normal control group,model group,vitamin E and low, middle and high dosage of yunke.The content of MDA（malondialdehyde）,the activity of SOD（superoxide dismutase）,GSH-PX（glutathione peroxidase） and MAO（monoamine oxidase） in liver were determined when the mice were killed after 6 weeks. Results Yunke could significantly improve the activity of SOD,GSH-PX,and decrease contents of MDA and MAO in liver.The administration of yunke and vitamin E showed no different degrees of elevating the SOD,GSH-PX activities,and reducing the content of MDA and MAO in liver.Compared with the normal control group,the activity of SOD and GSH-PX were reduced significantly in the liver of the model group,the MDA and MAO content of liver was increased.Conclusions Yunke plays the role of anti-oxidation and anti-aging by protecting the body from free radical damage.

关 键 词：云克 亚急性衰老小鼠 抗氧化 

分 类 号：R817.4[医药卫生—影像医学与核医学]