动态随机分组方法介绍及应用  

Introduction of dynamic balancing randomization method and its application

作　　者：刘兆兰[1] 刘宝全 李兰花[3] 刘建平[1] 

机构地区：[1]北京中医药大学基础医学院循证医学中心,北京100029 [2]中国农业银行信息中心信息系统管理处,北京100005 [3]潍坊医学院预防医学系,山东潍坊261053

出　　处：《中西医结合学报》2011年第3期246-251,共6页Journal of Chinese Integrative Medicine

基　　金：国家重点基础研究发展计划(973计划)资助项目(No.2006CB504602);国家科技部国际合作资助项目(No.2009DFA31460)

摘　　要：随着临床试验的广泛开展,临床试验的方法学要素也得到不断发展,如随机分组方法和盲法等。随机分组的方法有完全随机和分层区组随机等,动态随机分组也被认为是一种随机分组方法。本文介绍了两种动态随机分组方法,即仅考虑各组例数均衡的随机化法和考虑预后因素的随机化法,并以模拟和实例分别演示了两种类型动态随机分组方法的操作过程。Following the development of clinical trials,the methodology of clinical trials has developed a great deal,including randomization method and blinding method,etc.The method of randomization includes simple randomization,stratification randomization,etc.Dynamic randomization is also considered as a method of randomization.Two dynamic randomization methods are introduced in this paper,including a method considering the balance of numbers in each group and a method considering prognostic factors.This paper also demonstrates the procedure of dynamic randomization of the above two methods by simulations and actual examples.

关 键 词：统计学 随机分配 偏币法 瓮法 

分 类 号：R195[医药卫生—卫生统计学]