我院3673株临床分离菌与药敏分析  

Drug-sensitivity analysis of the 3 673 clinical isolated bacillus strains in our hospital

作　　者：李炜清[1] 

机构地区：[1]上海市第二人民医院药剂科,上海200011

出　　处：《中国临床药学杂志》2011年第2期95-101,共7页Chinese Journal of Clinical Pharmacy

摘　　要：目的了解我院抗菌药物应用与病原菌耐药现状,探讨抗菌药物用量与细菌耐药性变迁之间的关系,指导临床合理用药。方法收集、统计对比分析2007-2008年住院部常用抗菌药物应用频度与病原菌的耐药率。结果 2a来,11种抗菌药物应用频度(DDDs)增长迅速,增长率>20%。病原菌监测结果显示标本阳性率55.88%,其中革兰阴性杆菌56.39%,革兰阳性球菌13.58%,真菌28.65%,主要分布于呼吸道、泌尿道、皮肤与组织。分离率排序前5位的病原菌分别是大肠埃希菌、肺炎克雷伯杆菌、金黄色葡萄球菌、鲍曼不动杆菌和铜绿假单胞菌,多药耐药菌株分离率及耐药率以不同程度逐年上升。结论需要加强临床抗菌药物应用管理与细菌耐药谱的监测,延缓及防止细菌耐药菌株的产生与传播。AIM To investigate the use of antibacterials,microbial resistance and trends,to explore the relationship between antibacterial consumption and resistance rate of pathogenic bacteria in order to guide rational drug usage in the clinic.METHODS The defined daily doses（DDDs） of antibacterial drugs and drug resistance rates from 2007 to 2008 were collected and analyzed statistically in the inpatients.RESULTS The DDDs of 11 antibacterials showed a great increase in the 2 years.The monitored results of pathogenic bacteria showed that the detectionrate of pathogenic bacteria was 55.88%,of which 56.39%were gram-negative bacilli,13.58%were gram-positive cocci,and 28.65%were fungi, which were mostly found in respiratory tract,urinarytract,skin and tissues.Leading the first 5 places in the list of the isolated clinical pathogenic bacteria were Escherichia coli,Klebsiella pneumoniae,Staphylococcus aureus,Acinetobacter baumanii and Pseudomonastdrug,respectively.The isolatedrate and resistance rate of pathogens were increasing year by year with varying degrees.CONCLUSION It is necessary to strengthen the administration of the clinical use of antibacterial drug and the monitoring of the cbnical resistance,in order to delay and prevent the occurrence and spreading of bacteria resistance;drug-sensitivity analysis

关 键 词：抗菌药物 限定日剂量 耐药率 合理用药 药敏分析 

分 类 号：R446.5[医药卫生—诊断学]