Tributylphosphine-catalyzed reaction of ethanethiol with alkynyl ketones  

作　　者：Shen Zhao Qing Fa Zhou Jia Zhi Liu Wei Fang Tang Tao Lu 

机构地区：[1]Department of Organic Chemistry,China Pharmaceutical University,Nanjing 210009,China [2]Key Laboratory of Drug Quality Control and Pharmacovigilance,China Pharmaceutical University, Ministry of Education,Nanjing 210009,China

出　　处：《Chinese Chemical Letters》2011年第4期397-400,共4页中国化学快报（英文版）

基　　金：support from National Natural Science Foundation of China(No.30973609)

摘　　要：A stereoselective and effective method for the synthesis of vinyl thioethers has been developed.This method is based on the Michael addition of ethanethiol to various alkynyl ketones using 10 mol%of tributylphosphine as catalyst.Most of alkynyl ketones react with ethanethiol in this system to yield mainly Z-isomer of vinyl thioether adducts,only in one case mainly E-isomer of vinyl thioether adducts was observed.A stereoselective and effective method for the synthesis of vinyl thioethers has been developed.This method is based on the Michael addition of ethanethiol to various alkynyl ketones using 10 mol%of tributylphosphine as catalyst.Most of alkynyl ketones react with ethanethiol in this system to yield mainly Z-isomer of vinyl thioether adducts,only in one case mainly E-isomer of vinyl thioether adducts was observed.

关 键 词：TRIBUTYLPHOSPHINE SYNTHESIS Alkynyl ketones Michael addition Vinyl thioether 

分 类 号：O643.32[理学—物理化学] TQ658.91[理学—化学]